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成人抗癫痫药物的选择。

Selection of antiepileptic drugs in adults.

机构信息

Division of Cardiovascular and Medical Sciences, Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

Division of Cardiovascular and Medical Sciences, Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

出版信息

Neurol Clin. 2009 Nov;27(4):967-992. doi: 10.1016/j.ncl.2009.06.007.

DOI:10.1016/j.ncl.2009.06.007
PMID:19853218
Abstract

Epilepsy affects approximately 50 million people worldwide, with an annual incidence of 50 to 70 cases per 100,000 population. The condition can strike at any time of life, with an immediate impact on everyday activities and routine. Key to optimal management is swift referral to an epilepsy specialist, appropriate investigation, and timely institution of antiepileptic drug therapy. In the past 20 years, the explosion of 13 new agents into the marketplace has greatly increased the potential for therapeutic intervention. This article explores the rationale for treatment selection in adults with epilepsy.

摘要

癫痫影响全球约 5000 万人,每年每 10 万人中有 50 至 70 例新发病例。这种情况可能在任何年龄段发作,直接影响日常活动和日常生活。最佳管理的关键是迅速转介给癫痫专家,进行适当的检查,并及时开始抗癫痫药物治疗。在过去的 20 年中,市场上出现了 13 种新药物,大大增加了治疗干预的可能性。本文探讨了成人癫痫治疗选择的原理。

相似文献

1
Selection of antiepileptic drugs in adults.成人抗癫痫药物的选择。
Neurol Clin. 2009 Nov;27(4):967-992. doi: 10.1016/j.ncl.2009.06.007.
2
The selection of antiepileptic drugs for the treatment of epilepsy in children and adults.儿童和成人癫痫治疗中抗癫痫药物的选择。
Neurol Clin. 2010 Nov;28(4):843-52. doi: 10.1016/j.ncl.2010.03.026.
3
The pharmacological treatment of epilepsy in adults.成人癫痫的药物治疗。
Lancet Neurol. 2011 May;10(5):446-56. doi: 10.1016/S1474-4422(11)70047-3.
4
Rhabdomyolysis induced by antiepileptic drugs: characteristics, treatment and prognosis.抗癫痫药物所致横纹肌溶解症:特点、治疗及预后
Expert Opin Drug Saf. 2016;15(3):357-65. doi: 10.1517/14740338.2016.1139572. Epub 2016 Feb 20.
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Future antiepileptic drug development.未来抗癫痫药物的研发。
Neurology. 2000;55(5 Suppl 1):S47-53; discussion S54-8.
6
Antiepileptic drug selection in pediatric epilepsy.小儿癫痫的抗癫痫药物选择
J Child Neurol. 2002 Feb;17 Suppl 2:2S2-2S8. doi: 10.1177/08830738020170020701.
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Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.抗癫痫药物治疗的优化。血清药物浓度监测的重要性。
Clin Pharmacokinet. 1996 Aug;31(2):120-30. doi: 10.2165/00003088-199631020-00004.
8
Novel therapeutic targets for epilepsy intervention.癫痫干预的新治疗靶点。
Seizure. 2017 Oct;51:27-34. doi: 10.1016/j.seizure.2017.07.014. Epub 2017 Jul 25.
9
Best clinical and research practice in epilepsy of older people: Focus on antiepileptic drug adherence.老年人癫痫的最佳临床与研究实践:聚焦抗癫痫药物依从性。
Epilepsy Behav. 2009 Jun;15 Suppl 1:S60-3. doi: 10.1016/j.yebeh.2009.03.010. Epub 2009 Apr 11.
10
Management of epilepsy in adolescents and adults.青少年及成人癫痫的管理
Lancet. 2000 Jul 22;356(9226):323-9. doi: 10.1016/S0140-6736(00)02515-0.

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The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond.抗癫痫药物的药理学和临床疗效:从溴化物盐到依诺巴比妥及其他。
CNS Drugs. 2021 Sep;35(9):935-963. doi: 10.1007/s40263-021-00827-8. Epub 2021 Jun 18.
3
Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.
新诊断癫痫患者使用现有和新型抗癫痫药物治疗的治疗结局:一项长达 30 年的纵向队列研究。
JAMA Neurol. 2018 Mar 1;75(3):279-286. doi: 10.1001/jamaneurol.2017.3949.
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2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs.2015年美国兽医内科学会犬癫痫发作管理小动物共识声明。
J Vet Intern Med. 2016 Mar-Apr;30(2):477-90. doi: 10.1111/jvim.13841. Epub 2016 Feb 22.
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International Veterinary Epilepsy Task Force consensus proposal: medical treatment of canine epilepsy in Europe.国际兽医癫痫特别工作组共识提案:欧洲犬癫痫的药物治疗
BMC Vet Res. 2015 Aug 28;11:176. doi: 10.1186/s12917-015-0464-z.
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Patterns of treatment response in newly diagnosed epilepsy.新诊断癫痫的治疗反应模式。
Neurology. 2012 May 15;78(20):1548-54. doi: 10.1212/WNL.0b013e3182563b19. Epub 2012 May 9.
7
Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment.用于癫痫和发作的药物概述:病因、诊断与治疗
P T. 2010 Jul;35(7):392-415.