• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中央马传贫螺旋体亚种的全基因组序列。

Complete genome sequence of Anaplasma marginale subsp. centrale.

机构信息

Animal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington 99164, USA.

出版信息

J Bacteriol. 2010 Jan;192(1):379-80. doi: 10.1128/JB.01330-09.

DOI:10.1128/JB.01330-09
PMID:19854912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2798241/
Abstract

Anaplasma marginale subsp. centrale is a naturally attenuated subtype that has been used as a vaccine for a century. We sequenced the genome of this organism and compared it to those of virulent senso stricto A. marginale strains. The comparison markedly narrows the number of outer membrane protein candidates for development of a safer inactivated vaccine and provides insight into the diversity among strains of senso lato A. marginale.

摘要

中央绵羊无浆体亚种是一种天然减毒亚型，已经被用作疫苗长达一个世纪。我们对该生物体的基因组进行了测序，并将其与强毒的严格意义上的边缘无浆体菌株进行了比较。比较结果显著缩小了用于开发更安全的灭活疫苗的外膜蛋白候选物的数量，并深入了解了宽义上的边缘无浆体菌株之间的多样性。

相似文献

1
Complete genome sequence of Anaplasma marginale subsp. centrale.中央马传贫螺旋体亚种的全基因组序列。
J Bacteriol. 2010 Jan;192(1):379-80. doi: 10.1128/JB.01330-09.
2
Identification of Anaplasma marginale outer membrane protein antigens conserved between A. marginale sensu stricto strains and the live A. marginale subsp. centrale vaccine.鉴定严格意义上的边缘无浆体菌株和活的边缘无浆体亚种中央疫苗之间保守的边缘无浆体外膜蛋白抗原。
Infect Immun. 2011 Mar;79(3):1311-8. doi: 10.1128/IAI.01174-10. Epub 2010 Dec 28.
3
Characterization of Anaplasma marginale subsp. centrale Strains by Use of msp1aS Genotyping Reveals a Wildlife Reservoir.利用msp1aS基因分型对边缘无形体中央亚种菌株进行鉴定揭示了野生动物宿主。
J Clin Microbiol. 2016 Oct;54(10):2503-12. doi: 10.1128/JCM.01029-16. Epub 2016 Jul 20.
4
Molecular conservation of MSP4 and MSP5 in Anaplasma marginale and A. centrale vaccine strain.边缘无形体和中央无形体疫苗株中MSP4和MSP5的分子保守性
Vet Microbiol. 2004 May 20;100(1-2):55-64. doi: 10.1016/j.vetmic.2004.01.018.
5
Identification of a T-Cell Epitope That Is Globally Conserved among Outer Membrane Proteins (OMPs) OMP7, OMP8, and OMP9 of Anaplasma marginale Strains and with OMP7 from the A. marginale subsp. centrale Vaccine Strain.在边缘无形体菌株的外膜蛋白（OMP）OMP7、OMP8和OMP9中以及与边缘无形体中央亚种疫苗株的OMP7之间全局保守的T细胞表位的鉴定
Clin Vaccine Immunol. 2017 Jan 5;24(1). doi: 10.1128/CVI.00406-16. Print 2017 Jan.
6
Anaplasma marginale outer membrane protein vaccine candidates are conserved in North American and South African strains.边缘无浆体属外膜蛋白疫苗候选物在北美和南非分离株中保守。
Ticks Tick Borne Dis. 2020 Jul;11(4):101444. doi: 10.1016/j.ttbdis.2020.101444. Epub 2020 Apr 18.
7
Co-infections with multiple genotypes of Anaplasma marginale in cattle indicate pathogen diversity.牛的边缘无浆体多种基因型的合并感染表明病原体的多样性。
Parasit Vectors. 2018 Jan 3;11(1):5. doi: 10.1186/s13071-017-2595-5.
8
First molecular survey and novel genetic variants' identification of Anaplasma marginale, A. centrale and A. bovis in cattle from Tunisia.突尼斯牛中边缘无浆体、中央无浆体和牛无浆体的首次分子调查及新型基因变异体鉴定
Infect Genet Evol. 2015 Aug;34:361-71. doi: 10.1016/j.meegid.2015.06.017. Epub 2015 Jun 24.
9
Multistrain genome analysis identifies candidate vaccine antigens of Anaplasma marginale.多株系基因组分析鉴定出边缘无浆体的候选疫苗抗原。
Vaccine. 2011 Jul 12;29(31):4923-32. doi: 10.1016/j.vaccine.2011.04.131. Epub 2011 May 17.
10
Molecular detection and phylogenetic analysis of Anaplasma marginale and Anaplasma centrale amongst transhumant cattle in north-eastern Uganda.分子检测和进化分析在乌干达东北部的游牧牛群中的边缘无浆体和中央无浆体。
Ticks Tick Borne Dis. 2018 Mar;9(3):580-588. doi: 10.1016/j.ttbdis.2018.01.012. Epub 2018 Feb 1.

引用本文的文献

1
Temporal changes in the bacterial microbiome of the salivary gland and midgut tissues of Rhipicephalus sanguineus (s.l.) ticks in South Africa.南非血红扇头蜱（广义）唾液腺和中肠组织细菌微生物群的时间变化。
Sci Rep. 2025 May 20;15(1):17434. doi: 10.1038/s41598-025-99189-0.
2
Genomic characters of and genetic diversity in China.中国 和 的基因组特征及遗传多样性。
Emerg Microbes Infect. 2024 Dec;13(1):2323153. doi: 10.1080/22221751.2024.2323153. Epub 2024 Mar 5.
3
Immunization with Msp2 HVRs Is Less Effective than the Live Vaccine against Anaplasmosis.用Msp2高变区进行免疫接种预防无形体病的效果不如活疫苗。
Vaccines (Basel). 2023 Sep 29;11(10):1544. doi: 10.3390/vaccines11101544.
4
Unravelling the diversity of species circulating in selected African wildlife hosts by targeted 16S microbiome analysis.通过靶向16S微生物组分析揭示选定非洲野生动物宿主中传播的物种多样性。
Curr Res Microb Sci. 2023 Aug 6;5:100198. doi: 10.1016/j.crmicr.2023.100198. eCollection 2023.
5
Genomic Characteristics of Emerging Intraerythrocytic Anaplasma capra and High Prevalence in Goats, China.中国红细胞内新兴绵羊无形体的基因组特征及其在山羊中的高流行率。
Emerg Infect Dis. 2023 Sep;29(9):1780-1788. doi: 10.3201/eid2909.230131.
6
Diversity and phylogeny of the tick-borne bacterial genus Candidatus Allocryptoplasma (Anaplasmataceae).蜱传细菌属“候选立克次体支原体”（立克次体科）的多样性和系统发育。
Parasite. 2023;30:13. doi: 10.1051/parasite/2023014. Epub 2023 May 10.
7
Molecular Detection of Tick-Borne Rickettsial Pathogens Associated with the Arabian Camel (Camelus dromedarius) in Riyadh and the Eastern Region, Saudi Arabia.沙特阿拉伯利雅得和东部地区与阿拉伯单峰驼（Camelus dromedarius）相关的蜱传立克次体病原体的分子检测。
Acta Parasitol. 2022 Jun;67(2):794-801. doi: 10.1007/s11686-022-00520-w. Epub 2022 Feb 2.
8
Multiple vector-borne pathogens of domestic animals in Egypt.埃及家养动物的多种媒介传播病原体。
PLoS Negl Trop Dis. 2021 Sep 29;15(9):e0009767. doi: 10.1371/journal.pntd.0009767. eCollection 2021 Sep.
9
The Anaplasma ovis genome reveals a high proportion of pseudogenes.绵羊无形体基因组揭示了高比例的假基因。
BMC Genomics. 2019 Jan 21;20(1):69. doi: 10.1186/s12864-018-5374-6.
10
Detection and Characterisation of Anaplasma marginale and A. centrale in South Africa.南非边缘无形体和中央无形体的检测与特征分析
Vet Sci. 2018 Mar 3;5(1):26. doi: 10.3390/vetsci5010026.

本文引用的文献

1
Conservation in the face of diversity: multistrain analysis of an intracellular bacterium.面对多样性时的保守性：一种细胞内细菌的多菌株分析
BMC Genomics. 2009 Jan 11;10:16. doi: 10.1186/1471-2164-10-16.
2
Composition of the surface proteome of Anaplasma marginale and its role in protective immunity induced by outer membrane immunization.边缘无形体表面蛋白质组的组成及其在外膜免疫诱导的保护性免疫中的作用。
Infect Immun. 2008 May;76(5):2219-26. doi: 10.1128/IAI.00008-08. Epub 2008 Mar 3.
3
Identifying bacterial genes and endosymbiont DNA with Glimmer.使用Glimmer识别细菌基因和内共生体DNA。
Bioinformatics. 2007 Mar 15;23(6):673-9. doi: 10.1093/bioinformatics/btm009. Epub 2007 Jan 19.
4
Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins.边缘无形体msp2基因超家族外膜蛋白的差异表达与序列保守性
Infect Immun. 2006 Jun;74(6):3471-9. doi: 10.1128/IAI.01843-05.
5
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.边缘无形体的全基因组测序表明，其表面偏向于两个外膜蛋白超家族。
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):844-9. doi: 10.1073/pnas.0406656102. Epub 2004 Dec 23.
6
Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila.立克次氏体目里克次体科和无形体科属的重新分类：将埃立克体属的一些物种与无形体属合并、考德里体属与埃立克体属合并以及埃立克体属与新立克次体属合并，六个新物种组合的描述以及将马埃立克体和“人粒细胞埃立克体病病原体”指定为嗜吞噬细胞埃立克体的主观同义词。
Int J Syst Evol Microbiol. 2001 Nov;51(Pt 6):2145-2165. doi: 10.1099/00207713-51-6-2145.
7
Improved microbial gene identification with GLIMMER.利用GLIMMER改进微生物基因识别。
Nucleic Acids Res. 1999 Dec 1;27(23):4636-41. doi: 10.1093/nar/27.23.4636.
8
Molecular basis for vaccine development against the ehrlichial pathogen Anaplasma marginale.
Parasitol Today. 1999 Jul;15(7):281-6. doi: 10.1016/s0169-4758(99)01469-6.
9
Microbial gene identification using interpolated Markov models.使用插值马尔可夫模型进行微生物基因识别。
Nucleic Acids Res. 1998 Jan 15;26(2):544-8. doi: 10.1093/nar/26.2.544.
10
Live vaccines against hemoparasitic diseases in livestock.针对家畜血液寄生虫病的活疫苗。
Vet Parasitol. 1995 Mar;57(1-3):213-31. doi: 10.1016/0304-4017(94)03122-d.