Animal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington 99164, USA.
J Bacteriol. 2010 Jan;192(1):379-80. doi: 10.1128/JB.01330-09.
Anaplasma marginale subsp. centrale is a naturally attenuated subtype that has been used as a vaccine for a century. We sequenced the genome of this organism and compared it to those of virulent senso stricto A. marginale strains. The comparison markedly narrows the number of outer membrane protein candidates for development of a safer inactivated vaccine and provides insight into the diversity among strains of senso lato A. marginale.
中央绵羊无浆体亚种是一种天然减毒亚型,已经被用作疫苗长达一个世纪。我们对该生物体的基因组进行了测序,并将其与强毒的严格意义上的边缘无浆体菌株进行了比较。比较结果显著缩小了用于开发更安全的灭活疫苗的外膜蛋白候选物的数量,并深入了解了宽义上的边缘无浆体菌株之间的多样性。