Dipartimento di Scienze per la Promozione della Salute G. D'Alessandro, Sezione di Microbiologia, Università di Palermo, Palermo, Italy.
J Med Virol. 2009 Dec;81(12):2089-95. doi: 10.1002/jmv.21615.
In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6, and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4, and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.
近年来，全世界范围内检测到 G3P[8]轮状病毒的频率明显增加。同样，在意大利，G3P[8]株在过去 20 年中也呈零星和分散的方式检测到，而在 2003 年和 2005 年，G3P[8]轮状病毒的活性显著增加。通过对 1993 年至 2005 年间检测到的一组 G3P[8]轮状病毒的 VP7、VP4、VP6 和 NSP4 基因进行分析，观察到 VP7、VP4 和 VP6 基因具有显著的序列保守性。相反，2002 年后，意大利的 G3P[8]株被发现 NSP4 蛋白的重要区域存在独特的突变。
