猪A组轮状病毒G6P[13]株中VP6和NSP4编码基因独立分离的证据
Evidence for independent segregation of the VP6- and NSP4- encoding genes in porcine group A rotavirus G6P[13] strains.
作者信息
Ghosh S, Varghese V, Samajdar S, Bhattacharya S K, Kobayashi N, Naik T N
机构信息
Division of Virology, National Institute of Cholera and Enteric Diseases, Kolkata, India.
出版信息
Arch Virol. 2007 Feb;152(2):423-9. doi: 10.1007/s00705-006-0848-2. Epub 2006 Sep 28.
Molecular characterization of two porcine group A rotavirus strains (HP113 and HP140), detected from eastern India, revealed a VP7 closely related to those of human G6P[14] strains, VP4 with a borderline P[13] genotype, and VP6 related to bovine and human SGI strains rather than porcine SGI and/or SGII group A rotaviruses. Both strains had NSP4 and NSP5 of porcine origin. Therefore, to our knowledge, the present study is the first report of detection of group A rotavirus strains with G6P[13] genotype specificities and provides evidence for independent segregation of the VP6- and NSP4-encoding genes in porcine group A rotaviruses.
从印度东部检测到的两株猪A组轮状病毒（HP113和HP140）的分子特征显示，VP7与人类G6P[14]毒株的VP7密切相关，VP4具有临界P[13]基因型，VP6与牛和人类SGI毒株相关，而非猪SGI和/或SGII A组轮状病毒。两株病毒均具有猪源的NSP4和NSP5。因此，据我们所知，本研究是首次检测到具有G6P[13]基因型特异性的A组轮状病毒毒株的报告，并为猪A组轮状病毒中VP6和NSP4编码基因的独立分离提供了证据。
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