Iwata Fumie, Sato Seizo, Mukai Takako, Yamada Shoichi, Takeo Jiro, Abe Akihisa, Okita Takaaki, Kawahara Hiroyuki
Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi Hachioji, Tokyo 192-0906, Japan.
J Nat Prod. 2009 Nov;72(11):2046-8. doi: 10.1021/np900353y.
A marine-derived actinomyces strain (NPS554) isolated from a marine sediment sample collected from Miyazaki Harbor, Japan, at a depth of 38 m yielded two trialkyl-substituted aromatic acids, lorneic acid A (1) and lorneic acid B (2). The structures of the lorneic acids, which were elucidated by spectroscopic analysis, differed only in the side-chain, which contained either a conjugated double bond or a benzylic alcohol. Their structural differences affected inhibition activities against phosphodiesterase 5.
从日本宫崎港38米深处采集的海洋沉积物样本中分离出的一株海洋放线菌（NPS554）产生了两种三烷基取代的芳香酸，洛尼酸A（1）和洛尼酸B（2）。通过光谱分析阐明的洛尼酸的结构仅在侧链上有所不同，侧链含有共轭双键或苄醇。它们的结构差异影响了对磷酸二酯酶5的抑制活性。
