Franceschi S, Bidoli E, Barón A E, Barra S, Talamini R, Serraino D, La Vecchia C
Epidemiology Unit, Aviano Cancer Center, Italy.
Int J Cancer. 1991 Jan 2;47(1):20-5. doi: 10.1002/ijc.2910470105.
The relation between dietary indicators and the risk of cancer of the oral cavity and pharynx was investigated in a case-control study conducted in Pordenone province, north-east Italy, on 302 cases (266 males and 36 females) and 699 controls admitted to hospital for acute, non-neoplastic and non-digestive disorders. Positive associations were observed, after allowing for occupation, smoking and drinking habits, with more frequent consumption of pasta or rice, polenta, cheese, eggs and pulses (odds ratios - ORs = 1.6, 2.1, 1.9, 1.9 and 2.0 for highest vs. lowest tertile), whereas reduced ORs emerged in subjects reporting more frequent consumption of carrots, fresh tomatoes and green peppers (ORs = 0.6, 0.5 and 0.5, respectively). Higher frequency of daily meals was also associated with a significantly elevated OR (1.7 for greater than or equal to 4 vs. less than or equal to 2 meals). The role of various indicator foods must be assessed in the context of the very high levels of alcohol consumption in the study area (greater than or equal to 8 alcoholic drinks/day in 2/3 cancer cases).
在意大利东北部的波代诺内省开展的一项病例对照研究中，调查了饮食指标与口腔癌和咽癌风险之间的关系。该研究纳入了302例病例（266例男性和36例女性）以及699例因急性、非肿瘤性和非消化系统疾病入院的对照。在考虑职业、吸烟和饮酒习惯后，观察到与面食或米饭、玉米粥、奶酪、鸡蛋和豆类的更频繁消费呈正相关（最高三分位数与最低三分位数相比，优势比 - OR分别为1.6、2.1、1.9、1.9和2.0），而报告胡萝卜、新鲜番茄和青椒消费更频繁的受试者中OR降低（OR分别为0.6、0.5和0.5）。每日进餐频率较高也与显著升高的OR相关（4餐及以上与2餐及以下相比，OR为1.7）。在研究地区酒精消费量非常高的背景下（三分之二的癌症病例中酒精摄入量≥8杯/天），必须评估各种指示性食物的作用。
