Retina Service, Institute of Ophthalmology, Aligarh Muslim University, Aligarh, India.
Indian J Ophthalmol. 2009 Nov-Dec;57(6):419-22. doi: 10.4103/0301-4738.57143.
The preferential occurrence of idiopathic central serous chorioretinopathy (ICSC) in males with a typical Type A personality and behavior and a relative absence in females is a possible indicator towards the role of serum cortisol and /or the male sex hormone testosterone.
To study levels of cortisol and testosterone in ICSC.
Case-control study in a tertiary care teaching hospital.
The study was conducted on 23 cases of ICSC. Twelve patients with unilateral sudden painless loss of vision of less than one month duration served as controls. Serum cortisol and testosterone levels at 8.00 a.m. were estimated by radioimmunoassay in both groups.
Statistical analysis was done using SPSS 13.0 software. Independent Sample t-test was applied to analyze statistical significance between the two groups.
Mean age of patients with ICSC was 37.1 +/- 9.7 years and 96% of the patients were males. Mean serum cortisol levels were significantly higher (P=0.002) in patients with ICSC i.e., 495.02 +/- 169.47 nano moles/liter (nmol/L) as compared to controls i.e., 362.25 +/- 51.54 nmol/L. Mean serum testosterone levels were 3.85 +/- 1.81 nano grams/ml (ngm/ml) and 4.23 +/- 1.89 ngm/ml in cases and controls respectively and the difference was not statistically significant (P=0.58).
ICSC is associated with elevated 8.00 a.m. serum cortisol levels. However, mean serum testosterone levels in both patients of ICSC and controls were within normal range.
特发性中心性浆液性脉络膜视网膜病变（ICSC）在具有典型 A 型人格和行为的男性中优先发生，而在女性中相对较少，这可能表明血清皮质醇和/或男性性激素睾酮的作用。
研究 ICSC 中的皮质醇和睾酮水平。
在三级保健教学医院进行的病例对照研究。
该研究共纳入 23 例 ICSC 患者。12 例单侧突发性无痛性视力丧失时间小于 1 个月的患者作为对照组。两组均于上午 8 时采用放射免疫法测定血清皮质醇和睾酮水平。
采用 SPSS 13.0 软件进行统计分析。采用独立样本 t 检验分析两组间的统计学意义。
ICSC 患者的平均年龄为 37.1 +/- 9.7 岁，96%的患者为男性。ICSC 患者的平均血清皮质醇水平显著升高（P=0.002），即 495.02 +/- 169.47 纳摩尔/升（nmol/L），而对照组为 362.25 +/- 51.54 nmol/L。ICSC 患者和对照组的平均血清睾酮水平分别为 3.85 +/- 1.81 纳克/毫升（ngm/ml）和 4.23 +/- 1.89 ngm/ml，差异无统计学意义（P=0.58）。
ICSC 与上午 8 时血清皮质醇水平升高有关。然而，ICSC 患者和对照组的平均血清睾酮水平均在正常范围内。
