Dai M, Bao Y P, Li N, Clifford G M, Vaccarella S, Snijders P J F, Huang R D, Sun L X, Meijer C J L M, Qiao Y L, Franceschi S
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France.
Br J Cancer. 2006 Jul 3;95(1):96-101. doi: 10.1038/sj.bjc.6603208. Epub 2006 Jun 13.
To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in the rural province of Shanxi, People's Republic of China, which has relatively high cervical cancer mortality rates, we interviewed and obtained cervical cell samples from 662 women aged 15-59 years. A total of 24 different HPV types were identified using a GP5+/6+-based PCR assay able to detect 44 different HPV types. Human papillomavirus prevalence was 14.8% overall and 9.6% among women without cervical abnormalities (14.2 and 8.9%, respectively, age standardised to the world standard population). Multiple-type infections accounted for 30.6% of all infections. By far the most commonly found type was HPV16 (5.7% of all women and 38.8% of HPV-positive women), followed by HPV 58, 52, 33 and 18. Unlike most previous studies published, HPV prevalence was lower among women younger than 35 years (8.7%) than those older than 35 years (17.8%). High-risk HPV types predominated in all age groups. Although low-risk HPV types were rare in young women, they became more common with increasing age. 92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only. No significant difference in HPV positivity was observed by educational level, sexual habits, reproductive history or use of contraceptive methods in this rural low-income Chinese population.
为调查中国宫颈癌死亡率相对较高的山西省农村地区人乳头瘤病毒（HPV）宫颈感染的患病率及其危险因素，我们对662名年龄在15至59岁的女性进行了访谈并采集了宫颈细胞样本。使用一种基于GP5+/6+的PCR检测方法，该方法能够检测44种不同的HPV类型，共鉴定出24种不同的HPV类型。HPV总体患病率为14.8%，在无宫颈异常的女性中为9.6%（分别按照世界标准人口进行年龄标准化后为14.2%和8.9%）。多重感染占所有感染的30.6%。到目前为止，最常见的类型是HPV16（占所有女性的5.7%，占HPV阳性女性的38.8%），其次是HPV 58、52、33和18。与之前发表的大多数研究不同，35岁以下女性的HPV患病率（8.7%）低于35岁以上女性（17.8%）。高危HPV类型在所有年龄组中占主导地位。虽然低危HPV类型在年轻女性中很少见，但随着年龄的增长变得更为常见。92.3%的宫颈上皮内瘤变3级女性感染了高危HPV类型，但无一仅感染低危类型。在这个中国农村低收入人群中，HPV阳性率在教育水平、性行为习惯、生育史或避孕方法使用方面未观察到显著差异。
