Li L K, Dai M, Clifford G M, Yao W Q, Arslan A, Li N, Shi J F, Snijders P J F, Meijer C J L M, Qiao Y L, Franceschi S
Department of Gynecological Oncology, Liaoning Provincial Tumor Hospital, 44 Xiaoheyan Road, Shenyang 110042, Liaoning Province, China.
Br J Cancer. 2006 Dec 4;95(11):1593-7. doi: 10.1038/sj.bjc.6603450. Epub 2006 Oct 31.
To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in Shenyang City, People's Republic of China, we interviewed and obtained cervical cell samples from 685 women aged 15-59 years enumerated from local population lists. Human papillomavirus DNA was detected in cervical cell samples using a GP5+/6+-based PCR assay for 44 HPV types. Human papillomavirus prevalence was 16.8% overall and 13.6% among women without cervical abnormalities (16.6% and 12.4%, respectively, age-standardised to the world standard population), with no significant trends in HPV prevalence by age group. Of the 32 types identified, high-risk HPV types predominated in all age groups, HPV16 being the most common (3.4% of all women), followed by HPV52 (2.5%) and 58 (1.9%). Multiple-type infections accounted for 31.3% of all infected women. Not being married, reporting multiple sexual partners and husband's extramarital sexual relationships were all significantly associated with being HPV-positive. The disclosure of a relatively high HPV prevalence in Shenyang, in comparison with other worldwide populations, raises important questions concerning the prevention of cervical cancer in China, especially given the promising efficacy of prophylactic HPV vaccines.
为调查中国沈阳市人乳头瘤病毒（HPV）宫颈感染的患病率及危险因素，我们从当地人口名单中抽取了685名年龄在15至59岁的女性进行访谈并采集宫颈细胞样本。采用基于GP5+/6+的PCR检测法对44种HPV类型在宫颈细胞样本中进行HPV DNA检测。HPV总体患病率为16.8%，宫颈无异常的女性中患病率为13.6%（分别按照世界标准人口进行年龄标准化后为16.6%和12.4%），各年龄组的HPV患病率无显著趋势。在检测出的32种类型中，高危HPV类型在所有年龄组中均占主导，HPV16最为常见（占所有女性的3.4%），其次是HPV52（2.5%）和HPV58（1.9%）。多重感染占所有感染女性的31.3%。未婚、报告有多个性伴侣以及丈夫有婚外性行为均与HPV阳性显著相关。与世界其他人群相比，沈阳地区相对较高的HPV患病率引发了关于中国宫颈癌预防的重要问题，特别是考虑到预防性HPV疫苗有良好的效果。
