Kanthaswamy S, Capitanio J P, Dubay C J, Ferguson B, Folks T, Ha J C, Hotchkiss C E, Johnson Z P, Katze M G, Kean L S, Kubisch H Michael, Lank S, Lyons L A, Miller G M, Nylander J, O'Connor D H, Palermo R E, Smith D G, Vallender E J, Wiseman R W, Rogers J
Department of Anthropology, University of California-Davis, CA 95616, USA.
J Med Primatol. 2009 Oct;38 Suppl 1:17-23. doi: 10.1111/j.1600-0684.2009.00371.x.
The National Primate Research Centers (NPRCs) established Working Groups (WGs) for developing resources and mechanisms to facilitate collaborations among non-human primate (NHP) researchers. Here we report the progress of the Genome Banking and the Genetics and Genomics WGs in developing resources to advance the exchange, analysis and comparison of NHP genetic and genomic data across the NPRCs. The Genome Banking WG has established a National NHP DNA bank comprising 1250 DNA samples from unrelated animals and family trios from the 10 NHP species housed within the NPRC system. The Genetics and Genomics WG is developing SNP arrays that will provide a uniform, highly informative, efficient and low-cost method for rhesus and long-tailed macaque genotyping across the eight NPRCs. This WG is also establishing a Biomedical Informatics Research Network-based portal for shared bioinformatics resources including vital statistics, genotype and population data and information on the National NHP DNA bank.
国家灵长类研究中心（NPRCs）成立了工作组（WGs），以开发资源和机制，促进非人类灵长类动物（NHP）研究人员之间的合作。在此，我们报告基因组库以及遗传学与基因组学工作组在开发资源方面取得的进展，这些资源旨在推动NPRCs之间非人类灵长类动物遗传和基因组数据的交换、分析与比较。基因组库工作组已建立了一个国家非人类灵长类动物DNA库，其中包含来自NPRC系统内饲养的10种非人类灵长类动物的1250份无关动物和三联体家庭的DNA样本。遗传学与基因组学工作组正在开发单核苷酸多态性（SNP）阵列，这将为八个NPRCs的恒河猴和食蟹猴基因分型提供一种统一、信息丰富、高效且低成本的方法。该工作组还在建立一个基于生物医学信息学研究网络的门户网站，用于共享生物信息学资源，包括生命统计数据、基因型和种群数据以及国家非人类灵长类动物DNA库的信息。
