溴马来酰亚胺：用于半胱氨酸选择性和可逆修饰的新型试剂。
Bromomaleimides: new reagents for the selective and reversible modification of cysteine.
机构信息
Department of Chemistry, University College London, 20 Gordon St, London, UK.
出版信息
Chem Commun (Camb). 2009 Nov 21(43):6583-5. doi: 10.1039/b915136b. Epub 2009 Sep 16.
DOI:10.1039/b915136b
PMID:19865657
Abstract
Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.
摘要
溴代马来酰亚胺能迅速且选择性地与半胱氨酸反应，生成硫代马来酰亚胺，后者可用膦还原再生半胱氨酸，也可用碱处理生成脱氢丙氨酸。
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