Ayer Clinical Laboratory, Pennsylvania Hospital, Philadelphia.
J Exp Med. 1927 Oct 31;46(5):793-805. doi: 10.1084/jem.46.5.793.
The characteristic appearances exhibited by the surface colonies of both S and R pneumococci in 24 and 48 hour cultures upon rabbit blood agar have been reviewed. Emphasis has been laid upon the behavior and structure of the colonies formed by R pneumococci, their frequent similarity to the colonies formed by certain strains of Streptococcus viridans, and their failure to undergo rapid autolysis in the first 48-96 hours, a phenomenon which is highly characteristic of the S pneumococcus colonies. With the S pneumococci it has been shown that "pseudo rough" colonies may be immediately produced under certain unfavorable cultural conditions but such changes in colony morphology as these do not indicate that complete dissociation has taken place and that the organisms may be classified as true R pneumococci.
已回顾了在兔血琼脂上培养 24 和 48 小时后，S 和 R 肺炎球菌表面菌落的特征表现。重点介绍了 R 肺炎球菌形成的菌落的行为和结构，它们经常与某些草绿色链球菌菌株形成的菌落相似，并且在最初的 48-96 小时内不会迅速自溶，这是 S 肺炎球菌菌落的一个高度特征。对于 S 肺炎球菌，已经表明，在某些不利的培养条件下，可能会立即产生“假粗糙”菌落，但这些菌落形态的变化并不表明完全解离已经发生，并且可以将这些生物体归类为真正的 R 肺炎球菌。
