实验性坏血病出血倾向的一个指标。

A CRITERION OF HEMORRHAGIC DIATHESIS IN EXPERIMENTAL SCURVY.

Grasslands Hospital Laboratory, Valhalla.

J Exp Med. 1931 Jan 31;53(2):289-97. doi: 10.1084/jem.53.2.289.

Abstract

The degree of scorbutic change in the vessels of animals with experimental scurvy can be roughly measured by establishing the amount of negative pressure required to produce petechial hemorrhages in the skin. 2. The test shows that the hemorrhagic diathesis in experimental scurvy develops earlier than any other known sign of the disease and that it persists in some degree throughout. 3. The response of the blood vessels to the administration of antiscorbutic substances is extremely rapid as shown by the test, but it varies with the amount of antiscorbutic given and its method of administration. 4. The changes in the resistance of the vessels follows a curve which rises towards recovery during the end of the 1st week on a scorbutic diet, reaches a peak in the 2nd week and then falls steadily during the remainder of the course of the disease. This indicates that the course of the disease is not constant and progressive. 5. The test may have clinical value in the diagnosis of scurvy.

摘要

通过建立在皮肤上产生瘀点性出血所需的负压量，可以大致衡量实验性坏血病动物血管的坏血病变化程度。
该试验表明，实验性坏血病的出血素质比任何其他已知疾病迹象都更早出现，并且在整个病程中都持续存在一定程度。
该试验表明，血管对抗坏血病物质的反应非常迅速，但它因给予的抗坏血病物质的量及其给药方式而异。
血管阻力的变化遵循一条曲线，即在坏血病饮食的第 1 周结束时向恢复方向上升，在第 2 周达到峰值，然后在疾病的剩余时间内稳步下降。这表明疾病的过程不是恒定和渐进的。
该试验在坏血病的诊断中可能具有临床价值。