实验性坏血病中的牙齿生长。
TOOTH GROWTH IN EXPERIMENTAL SCURVY.
机构信息
Laboratory of Physiological Chemistry, Teachers College, Columbia University, the Department of Pathology, Cornell University Medical College, New York, and Grasslands Hospital Laboratory, Valhalla.
出版信息
J Exp Med. 1930 Jun 30;52(1):57-64. doi: 10.1084/jem.52.1.57.
Abstract
- The incisor teeth of guinea pigs have a constant rate of growth in health. 2. Deprivation of Vitamin C causes the teeth to cease growing. Readministration of the vitamin restores the growth. 3. Administration of small amounts of antiscorbutic substance results in rates of growth roughly proportional to dosage. 4. Under standard experimental conditions used in the testing of foodstuffs for antiscorbutic value, the rate of tooth growth would appear to be a precise indication of the degree of scurvy, being more delicate than the Sherman score, and more constant as well as more simple, than the Höjer method. 5. Stress in terms of usage appears to exaggerate the scorbutic lesions in the teeth.
摘要
豚鼠的切牙在健康状态下持续生长。
缺乏维生素 C 会导致牙齿停止生长。重新给予维生素 C 可恢复生长。
给予少量抗坏血酸物质会导致生长速度与剂量大致成比例。
在测试食品抗坏血病价值的标准实验条件下，牙齿生长速度似乎是坏血病程度的精确指标，比谢尔曼评分更灵敏，比霍耶尔法更稳定、更简单。
使用方面的压力似乎会使牙齿的坏血病病变恶化。
相似文献
1
TOOTH GROWTH IN EXPERIMENTAL SCURVY.实验性坏血病中的牙齿生长。
J Exp Med. 1930 Jun 30;52(1):57-64. doi: 10.1084/jem.52.1.57.
2
A CRITERION OF HEMORRHAGIC DIATHESIS IN EXPERIMENTAL SCURVY.实验性坏血病出血倾向的一个指标。
J Exp Med. 1931 Jan 31;53(2):289-97. doi: 10.1084/jem.53.2.289.
3
Antiscorbutic effect of dehydro-L-ascorbic acid in vitamin C-deficient guinea pigs.脱氢-L-抗坏血酸对维生素C缺乏豚鼠的抗坏血病作用。
J Nutr Sci Vitaminol (Tokyo). 1986 Apr;32(2):183-90. doi: 10.3177/jnsv.32.183.
4
Antiscorbutic activity of 6-bromo-6-deoxy-L-ascorbic acid in the guinea pig.6-溴-6-脱氧-L-抗坏血酸在豚鼠体内的抗坏血病活性
Int J Vitam Nutr Res. 1995;65(1):36-9.
5
The antiscorbutic action of L-ascorbic acid and D-isoascorbic acid (erythorbic acid) in the guinea pig.L-抗坏血酸和D-异抗坏血酸（异抗坏血酸）对豚鼠的抗坏血病作用。
Am J Clin Nutr. 1981 Jan;34(1):24-33. doi: 10.1093/ajcn/34.1.24.
6
[Comparative studies on the antiscorbutic effectiveness of L- and D-ascorbic acid in guinea pigs].[L-和D-抗坏血酸对豚鼠抗坏血病效果的比较研究]
Int Z Vitaminforsch. 1962;32:278-83.
7
The effect of rutin, a vitamin P-like substance, on the survival time of scorbutic guinea-pigs.类维生素P物质芦丁对坏血病豚鼠存活时间的影响。
J Egypt Med Assoc. 1953;36(1):1-13.
8
9
WOUND HEALING AND COLLAGEN FORMATION. IV. DISTORTION OF RIBOSOMAL PATTERNS OF FIBROBLASTS IN SCURVY.伤口愈合与胶原蛋白形成。IV. 坏血病中成纤维细胞核糖体模式的畸变。
J Cell Biol. 1964 Aug;22(2):365-89. doi: 10.1083/jcb.22.2.365.
10
Antiscorbutic activity of L-ascorbic acid 2-glucoside and its availability as a vitamin C supplement in normal rats and guinea pigs.L-抗坏血酸2-葡萄糖苷的抗坏血病活性及其作为维生素C补充剂在正常大鼠和豚鼠体内的可利用性。
J Pharmacobiodyn. 1990 Nov;13(11):688-95. doi: 10.1248/bpb1978.13.688.
引用本文的文献
1
Vitamin C: the known and the unknown and Goldilocks.维生素C：已知、未知与恰到好处的状态
Oral Dis. 2016 Sep;22(6):463-93. doi: 10.1111/odi.12446. Epub 2016 Apr 14.
2
NUTRITIONAL MUSCULAR DYSTROPHY IN THE GUINEA PIG AND RABBIT.豚鼠和兔的营养性肌肉萎缩症。
J Exp Med. 1931 Jul 31;54(2):145-65. doi: 10.1084/jem.54.2.145.
本文引用的文献
1
THE LESIONS IN THE SKELETAL MUSCLES IN EXPERIMENTAL SCORBUTUS.实验性坏血病骨骼肌中的损伤。
J Exp Med. 1929 Aug 31;50(3):293-8. doi: 10.1084/jem.50.3.293.
Zotero 插件