实验性兔皮肤肺炎球菌感染的病理学。
THE PATHOLOGY OF EXPERIMENTAL DERMAL PNEUMOCOCCUS INFECTION IN THE RABBIT.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1931 Jun 30;54(1):41-50. doi: 10.1084/jem.54.1.41.
Abstract
- The pathology of the experimental dermal pneumococcic infection in the rabbit is described in detail and the findings are compared with the histological alterations seen in the human pneumonic lung. There would appear to be a basic similarity of the lesions in both tissues. 2. A copious production of edema fluid is the outstanding characteristic of the early lesion. It occurs prior to any significant cellular change. In the spreading lesion an infiltration of the tissues with fluid precedes any other sign of reaction between tissue and microorganism. It seems likely that the advancing fluid carries with it the infecting organisms and inoculates all tissues which it reaches. The resulting infection seems not to take place by an active invasion of microorganisms but by a progressive inoculation from an infected fluid.
摘要
详细描述了兔实验性皮肤肺炎球菌感染的病理学，并将其发现与人类肺炎肺部的组织学改变进行了比较。这两种组织的病变似乎有基本的相似性。
大量的水肿液产生是早期病变的突出特征。它发生在任何明显的细胞变化之前。在扩散性病变中，组织浸润发生在组织与微生物之间发生任何其他反应之前。似乎前进的液体带着感染的生物体，并接种它所到达的所有组织。这种感染似乎不是通过微生物的主动入侵，而是通过受感染的液体的逐步接种而发生的。
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