家兔皮肤葡球菌病损的发展与定位。
THE DEVELOPMENT AND LOCALIZATION OF THE DERMAL PNEUMOCOCCIC LESION IN THE RABBIT.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1931 Nov 30;54(6):847-58. doi: 10.1084/jem.54.6.847.
Abstract
An attempt has been made to analyze the factors involved in the development and localization of the dermal pneumococcic lesion in the rabbit. The character and quantity of the edema fluid which forms during the early phases of the lesion are intimately concerned in its development and spread. It contains an antithrombic substance, probably derived from the pneumococci, and delayed coagulation probably facilitates its movement through the tissue. The direction of spread in the skin is determined by gravity, and the fluid finally localizes in the more dependent regions. The distance that the pneumococcic lesion travels and the local tissue characters have much to do with the amount of fluid that accumulates. Studies are also reported of some factors which alter the rate of spread of the edema fluid. An acceleration in rate occurs when H. influenzae is used as an associative infective agent with the Pneumococcus.
摘要
曾试图分析参与兔皮肤肺炎球菌病变发展和定位的因素。病变早期形成的水肿液的性质和数量与其发展和扩散密切相关。它含有一种抗血栓物质，可能来自肺炎球菌，而延迟的凝血可能有助于其在组织中的移动。在皮肤中的扩散方向由重力决定，液体最终在更依赖的区域定位。肺炎球菌病变的传播距离和局部组织特征与积聚的液体量有很大关系。还报告了一些改变水肿液扩散速度的因素的研究。当流感嗜血杆菌用作肺炎球菌的协同感染因子时，速度会加快。
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