检测 C 群溶血性链球菌感染引起豚鼠流行性淋巴管炎的皮肤试验：在种畜选择中的应用。
A SKIN TEST FOR DETECTING GROUP C HEMOLYTIC STREPTOCOCCAL INFECTION CAUSING EPIZOOTIC LYMPHADENITIS IN GUINEA PIGS : APPLICATIONS IN SELECTING BREEDING STOCK.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1936 Sep 30;64(4):553-8. doi: 10.1084/jem.64.4.553.
Abstract
- A skin test with a crude bacterial extract prepared from group C (Lancefield) hemolytic streptococci was used as a means of detecting possible carriers of the streptococcus causing epizootic lymphadenitis in guinea pigs. A positive test similar to a positive tuberculin reaction was considered presumptive evidence of present or recent infection with this streptococcus. 2. 20 positive reactors were found in 330 supposedly normal guinea pigs. 3. 195 negatively reacting animals were used as a breeding stock which yielded 1,296 progeny over a period of 15 months. None of the breeding stock or their progeny showed evidence of spontaneous lymphadenitis. Skin tests of 100 of the progeny were all negative. 4. The use of this skin test as a means of obtaining guinea pig breeding stock free of the streptococcus causing spontaneous lymphadenitis is suggested.
摘要
采用从 C 组（兰斯菲尔德）溶血性链球菌制备的粗制细菌提取物进行皮肤试验，作为检测引起豚鼠流行性淋巴结炎链球菌可能携带者的一种手段。阳性试验类似于阳性结核菌素反应，被认为是目前或近期感染这种链球菌的推定证据。
在 330 只据称正常的豚鼠中发现 20 个阳性反应者。
195 只阴性反应动物被用作繁殖种群，在 15 个月的时间里产生了 1296 头后代。繁殖种群或其后代均未出现自发性淋巴结炎的证据。对 100 头后代进行的皮肤试验均为阴性。
建议将这种皮肤试验作为获得无自发性淋巴结炎链球菌的豚鼠繁殖种群的一种手段。
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