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10
Antibody response of patients with poliomyelitis to virus recovered from their own alimentary tract.脊髓灰质炎患者对从其自身消化道分离出的病毒的抗体反应。
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本文引用的文献

1
ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : II. IMMUNIZATION WITH FORMOLIZED VIRUS.豚鼠的主动免疫接种马传染性脑脊髓炎病毒：Ⅱ.甲醛化病毒免疫接种。
J Exp Med. 1936 Apr 30;63(5):745-65. doi: 10.1084/jem.63.5.745.
2
EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST EXPERIMENTAL POLIOMYELITIS.主动免疫防治实验性脊髓灰质炎的实验。
J Exp Med. 1936 Jan 1;63(1):109-25. doi: 10.1084/jem.63.1.109.
3
THE EFFECTS OF NASALLY INSTILLED VIRUS OF POLIOMYELITIS ON THE CEREBROSPINAL FLUID AND THE BLOOD OF MONKEYS.鼻内接种脊髓灰质炎病毒对猴脑脊液和血液的影响。
J Exp Med. 1935 Nov 30;62(6):787-804. doi: 10.1084/jem.62.6.787.
4
AN ACCELERATED FEBRILE REACTION IN MONKEYS UPON REINOCULATION WITH POLIOMYELITIS VIRUS.猴体经脊髓灰质炎病毒再接种后出现加速发热反应。
J Exp Med. 1931 Jan 31;53(2):159-69. doi: 10.1084/jem.53.2.159.
5
EXPERIMENTAL EPIDEMIC POLIOMYELITIS IN MONKEYS.实验性猴脊髓灰质炎。
J Exp Med. 1910 Mar 14;12(2):227-55. doi: 10.1084/jem.12.2.227.
6
On the Problem of Immunization Against Poliomyelitis.关于脊髓灰质炎免疫接种问题。
Cal West Med. 1935 Aug;43(2):111-2.

体液抗体与接种和康复猴对脊髓灰质炎病毒的抵抗力。

HUMORAL ANTIBODIES AND RESISTANCE OF VACCINATED AND CONVALESCENT MONKEYS TO POLIOMYELITIS VIRUS.

机构信息

Laboratories of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1936 Oct 31;64(5):739-48. doi: 10.1084/jem.64.5.739.

DOI:10.1084/jem.64.5.739
PMID:19870565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2133445/
Abstract
  1. Monkeys convalescent from a paralytic attack of poliomyelitis develop humoral antibodies slowly; in the present series their first appearance in most was at 2 months and in some not until 3 months after the attack. 2. Convalescent monkeys display resistance to reinfection with the same strain by the nasal route long before antibodies become demonstrable in their serum, in this respect differing from many vaccinated monkeys whose serum neutralizes the virus, while they remain susceptible to nasal infection. 3. When antibodies appear in the serum of resistant convalescent monkeys, they are not quantitatively greater than in the serum of vaccinated monkeys which succumb to infection. As regards resistance to infection, humoral antibodies, therefore, do not have the same significance in vaccinated as in convalescent poliomyelitis monkeys.
摘要

  1. 从麻痹性脊髓灰质炎攻击中康复的猴子产生体液抗体的速度较慢；在本系列中，它们的首次出现大多在攻击后 2 个月，有些则直到 3 个月后。

  2. 恢复期猴子在血清中可检测到抗体之前，通过鼻腔途径对同一株病毒再次感染表现出抵抗力，这与许多接种疫苗的猴子不同，这些猴子的血清可以中和病毒，但它们仍然容易受到鼻腔感染。

  3. 当抗体出现在具有抵抗力的恢复期猴子的血清中时，它们的数量并不比感染后屈服的接种疫苗的猴子的血清中的抗体多。关于感染的抵抗力，因此，体液抗体在接种疫苗的脊髓灰质炎猴和恢复期脊髓灰质炎猴中的意义不同。