关于脑膜炎球菌感染的研究：十三. 抗荚膜多糖与保护小鼠免受 I 型脑膜炎球菌感染的抗体之间的相关性。
STUDIES ON MENINGOCOCCAL INFECTION : XIII. CORRELATION BETWEEN ANTIPOLYSACCHARIDE AND THE ANTIBODY WHICH PROTECTS MICE AGAINST INFECTION WITH TYPE I MENINGOCOCCI.
机构信息
Department of Bacteriology, The University of Rochester School of Medicine and Dentistry, Rochester, New York, and the Division of Microbiology, The Squibb Institute for Medical Research, New Brunswick, New Jersey.
出版信息
J Exp Med. 1945 Jan 1;81(1):85-92. doi: 10.1084/jem.81.1.85.
Absorption tests indicated that the protective antibody (Type I) in four antimeningococcal horse sera corresponded closely to one of the components of the polysaccharide preparation previously isolated by the authors from Type I meningococci. This antibody was, however, a minor fraction in the three therapeutic sera tested, being secondary in amount to non-protective antibody corresponding to another component of the polysaccharide preparation, plus antibody corresponding to agar. In one case, removal of the agar-antibody diminished the protective titer by 30 per cent.
吸收试验表明，从 4 份抗脑膜炎球菌马血清中分离出来的保护性抗体（I 型）与作者以前从 I 型脑膜炎球菌中分离出来的多糖制剂的一个成分密切相关。然而，在测试的三种治疗血清中，这种抗体是一个次要的组成部分，数量上仅次于另一个多糖制剂成分的非保护性抗体，加上与琼脂相对应的抗体。在一种情况下，去除琼脂抗体使保护效价降低了 30%。
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