Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden.
FEBS Lett. 2009 Dec 17;583(24):4025-9. doi: 10.1016/j.febslet.2009.10.069.
Signal transduction pathways control cellular responses to extrinsic and intrinsic signals. The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress. Pathway architecture as well as the flow of signal have been studied to a very high degree of detail. Recently, the yeast HOG pathway has become a popular model to analyse systems level properties of signal transduction. Those studies addressed, using experimentation and modelling, the role of basal signalling, robustness against perturbation, as well as adaptation and feedback control. These recent findings provide exciting insight into the higher control levels of signalling through this MAPK system of potential general importance.
信号转导途径控制细胞对外源和内源性信号的反应。酵母 HOG（高渗透压甘油）反应途径介导细胞对高渗胁迫的适应。该途径的结构以及信号的流向已经被研究到非常详细的程度。最近，酵母 HOG 途径已成为分析信号转导系统水平特性的流行模型。这些研究使用实验和建模方法，探讨了基础信号传递的作用、对扰动的鲁棒性，以及适应和反馈控制。这些最近的发现为通过这个 MAPK 系统对信号的更高控制水平提供了令人兴奋的见解，这可能具有普遍的重要性。
