Massachusetts Institute of Technology, Biology, Cambridge, MA 02139, USA.
J Bacteriol. 2010 Jan;192(1):365-9. doi: 10.1128/JB.01188-09.
Antibiotics are increasingly recognized as having other, important physiological functions for the cells that produce them. An example of this is the effect that phenazines have on signaling and community development for Pseudomonas aeruginosa (L. E. Dietrich, T. K. Teal, A. Price-Whelan, and D. K. Newman, Science 321:1203-1206, 2008). Here we show that phenazine-facilitated electron transfer to poised-potential electrodes promotes anaerobic survival but not growth of Pseudomonas aeruginosa PA14 under conditions of oxidant limitation. Other electron shuttles that are reduced but not made by PA14 do not facilitate survival, suggesting that the survival effect is specific to endogenous phenazines.
抗生素逐渐被认为对产生它们的细胞具有其他重要的生理功能。这方面的一个例子是苯醌对铜绿假单胞菌（L. E. Dietrich、T. K. Teal、A. Price-Whelan 和 D. K. Newman，Science 321:1203-1206，2008）信号和群落发育的影响。在这里，我们表明，苯醌促进电子转移到 poised-potential 电极，有助于铜绿假单胞菌 PA14 在氧化剂限制条件下的厌氧生存，但不能促进生长。其他被还原但不是由 PA14 产生的电子穿梭体不能促进生存，这表明生存效应是特定于内源性苯醌的。
