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The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer.转录因子Sox11是上皮性卵巢癌无复发生存改善的一个预后因素。
Eur J Cancer. 2009 May;45(8):1510-7. doi: 10.1016/j.ejca.2009.01.028. Epub 2009 Mar 9.
2
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.亚细胞Sox11分布模式可识别套细胞淋巴瘤亚群：与总生存期的相关性
Br J Haematol. 2008 Oct;143(2):248-52. doi: 10.1111/j.1365-2141.2008.07329.x. Epub 2008 Aug 20.
3
Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma.非B细胞谱系Sox11转录因子的核表达可识别套细胞淋巴瘤。
Blood. 2008 Jan 15;111(2):800-5. doi: 10.1182/blood-2007-06-093401. Epub 2007 Oct 12.
4
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.从基因表达分析到组织微阵列：一种在淋巴系统恶性肿瘤中识别治疗和诊断靶点的合理方法。
Mol Cell Proteomics. 2006 Jun;5(6):1072-81. doi: 10.1074/mcp.M600077-MCP200. Epub 2006 Mar 8.
5
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.细胞周期蛋白D1阴性套细胞淋巴瘤：一项基于基因表达谱分析的临床病理研究
Blood. 2005 Dec 15;106(13):4315-21. doi: 10.1182/blood-2005-04-1753. Epub 2005 Aug 25.
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Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.八聚体和Sox元件是Nanog基因表达转录顺式调控所必需的。
Mol Cell Biol. 2005 Mar;25(6):2475-85. doi: 10.1128/MCB.25.6.2475-2485.2005.
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Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas.转录因子SOX11在人类恶性胶质瘤中高度特异性过表达。
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Consistent immunostaining for cyclin D1 can be achieved on a routine basis using a newly available rabbit monoclonal antibody.使用一种新上市的兔单克隆抗体，可常规实现细胞周期蛋白D1的一致性免疫染色。
Am J Surg Pathol. 2004 Jun;28(6):801-7. doi: 10.1097/01.pas.0000126054.95798.94.
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Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.用于对人类组织中21号染色体基因产物进行系统蛋白质谱分析的亲和蛋白质组学。
Mol Cell Proteomics. 2003 Jun;2(6):405-14. doi: 10.1074/mcp.M300022-MCP200. Epub 2003 Jun 9.
10
Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections.通过对显微切割石蜡切片进行实时逆转录聚合酶链反应鉴定B细胞肿瘤中细胞周期蛋白D1信使核糖核酸的过表达
Clin Cancer Res. 2002 Sep;8(9):2902-11.

SOX11 转录因子的强淋巴核表达定义了淋巴母细胞肿瘤、套细胞淋巴瘤和伯基特淋巴瘤。

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

机构信息

Department of Pathology, Lund University Hospital, Sweden.

出版信息

Haematologica. 2009 Nov;94(11):1563-8. doi: 10.3324/haematol.2009.008474.

DOI:10.3324/haematol.2009.008474
PMID:19880779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2770967/
Abstract

BACKGROUND

We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1.

DESIGN AND METHODS

On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed.

RESULTS

Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas.

CONCLUSIONS

In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.

摘要

背景

我们调查了淋巴瘤，以确定套细胞淋巴瘤相关的 SOX11 转录因子的表达范围及其与 cyclin D1 的关系。

设计与方法

对 172 个标本进行了 SOX11 N 端和 C 端的免疫染色。通过免疫组织化学和定量逆转录聚合酶链反应检测 cyclin D1；当需要时应用 t（11；14）原位杂交。

结果

核 SOX11 在大多数 B 和 T 淋巴母细胞白血病/淋巴瘤和一半的儿童伯基特淋巴瘤中强烈表达，但在一些毛细胞白血病中表达较弱。慢性淋巴细胞白血病/淋巴瘤、边缘区、滤泡性和弥漫性大 B 细胞淋巴瘤均无 SOX11 表达，中间伯基特淋巴瘤/弥漫性大 B 细胞淋巴瘤、骨髓瘤、霍奇金淋巴瘤以及成熟 T 细胞和 NK/T 细胞淋巴瘤也均无 SOX11 表达。

结论

除了套细胞淋巴瘤外，SOX11 仅在淋巴母细胞性恶性肿瘤和伯基特淋巴瘤中强烈表达。其表达独立于 cyclin D1（除了在毛细胞白血病中表达较弱），不太可能是由于淋巴肿瘤中的易位所致。