Department of Cardiology, Odense University Hospital, Odense, Denmark.
J Intern Med. 2010 Apr;267(4):410-7. doi: 10.1111/j.1365-2796.2009.02163.x. Epub 2009 Aug 26.
Concentrations of osteoprotegerin (OPG) have been associated with the presence of vascular and cardiovascular diseases, but the knowledge of this marker in the setting of ischaemic stroke is limited.
In 244 patients with acute ischaemic stroke (age: 69 +/- 13 years), samples of OPG were obtained serially from presentation to day 5. Patients with overt ischaemic heart disease and atrial fibrillation were excluded. The patients were followed for 47 months, with all-cause mortality as the sole end-point. Multivariable predictors of OPG values at presentation included haemoglobin (T = -2.82; P = 0.005), creatinine (T = 4.56; P < 0.001), age (T = 9.66; P < 0.001), active smoking (T = 2.25; P = 0.025) and pulse rate (T = 3.23; P = 0.001). At follow-up 72 patients (29%) had died. Patients with OPG < or =2945 pg mL(-1) at baseline had a significantly improved survival rate on univariate analysis (P < 0.0001); other time-points did not add further prognostic information. In multivariate analysis, after adjustment for age, stroke severity, C-reactive protein levels, troponin T levels, heart and renal failure concentrations of OPG independently predicted long-term mortality after stroke (adjusted hazard ratio, 2.3; 95% CI: 1.1 to 4.9; P = 0.024).
Osteoprotegerin concentrations measured at admission of acute ischaemic stroke are associated with long-term mortality.
骨保护素（OPG）的浓度与血管和心血管疾病的发生有关，但在缺血性中风的情况下，对该标志物的了解有限。
在 244 例急性缺血性中风患者（年龄：69 +/- 13 岁）中，从发病时到第 5 天连续采集 OPG 样本。排除有明显缺血性心脏病和心房颤动的患者。对患者进行了 47 个月的随访，以全因死亡率作为唯一终点。发病时 OPG 值的多变量预测因素包括血红蛋白（T = -2.82；P = 0.005）、肌酐（T = 4.56；P < 0.001）、年龄（T = 9.66；P < 0.001）、主动吸烟（T = 2.25；P = 0.025）和脉搏率（T = 3.23；P = 0.001）。随访时 72 例（29%）患者死亡。在单变量分析中，基线 OPG < or =2945 pg mL(-1)的患者生存率显著提高（P < 0.0001）；其他时间点没有提供更多的预后信息。在多变量分析中，在调整年龄、中风严重程度、C 反应蛋白水平、肌钙蛋白 T 水平、心脏和肾功能衰竭后，OPG 浓度独立预测中风后长期死亡率（调整后的危险比，2.3；95%CI：1.1 至 4.9；P = 0.024）。
急性缺血性中风入院时测量的骨保护素浓度与长期死亡率相关。
