Agren M S, Chvapil M, Franzén L
Department of Pathology, Faculty of Health Sciences, Linköping, Sweden.
J Surg Res. 1991 Feb;50(2):101-5. doi: 10.1016/0022-4804(91)90230-j.
We investigated the effect of locally applied zinc on the healing of partial-thickness skin wounds in the domestic pig using two zinc compounds (zinc oxide and zinc sulfate) in two different vehicles (a gauze compress and a collagen sponge). The rate of re-epithelialization was determined morphometrically 48 and 64 hr after infliction of standardized square wounds (4.8 cm2 and 400-microns deep) with an electrokeratome. Zinc oxide in gauze significantly (P less than 0.05) increased re-epithelialization of the wounds (33% more epithelialized than control wounds after 64 hr) and in collagen sponge (76% more epithelialized than control wounds after 64 hr). Zinc sulfate had no such stimulatory effect at any dosage or vehicle used. Our results show that topical zinc oxide enhances re-epithelialization of partial-thickness wounds in nutritionally balanced pigs and that the mode of delivery of zinc is probably critical for achieving the beneficial healing effect of zinc.
我们使用两种锌化合物（氧化锌和硫酸锌）以及两种不同的载体（纱布敷料和胶原海绵），研究了局部应用锌对家猪部分厚度皮肤伤口愈合的影响。用电角膜刀造成标准化方形伤口（4.8平方厘米，深400微米）后48小时和64小时，通过形态计量学测定再上皮化速率。纱布中的氧化锌显著（P<0.05）增加了伤口的再上皮化（64小时后比对照伤口多33%的上皮化），胶原海绵中的氧化锌也有此效果（64小时后比对照伤口多76%的上皮化）。在所使用的任何剂量或载体下，硫酸锌均无此类刺激作用。我们的结果表明，局部应用氧化锌可增强营养均衡猪的部分厚度伤口的再上皮化，并且锌的给药方式可能对于实现锌的有益愈合效果至关重要。
