Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-cho, Kita-ku, Japan.
Int Arch Occup Environ Health. 2010 Feb;83(2):225-35. doi: 10.1007/s00420-009-0475-9.
This study explored possible associations between chemical substances and sick building syndrome (SBS)-type symptoms of residents living in new houses in Japan.
We randomly sampled 5,709 newly built conventional homes. In the end, 1,479 residents in 425 households completed a questionnaire survey and agreed to environmental monitoring for indoor aldehydes and volatile organic compounds (VOCs) to be conducted in their homes. If the residents had complained about at least one SBS-related symptom, they were classified as suffering from SBS. Multiple logistic regression analysis was used to select predictive chemical factors of SBS symptoms.
About 14% of the subjects suffered from SBS. Many aldehydes and VOCs were associated factors of optical, nasal, and gular symptoms in univariate analysis. After adjustment for other possible risk factors, formaldehyde dose-dependently showed to be a significant risk factor for SBS. Several chemicals had tendency to be associated with SBS symptoms.
Chemicals detected in Japanese newly built houses tend to increase the risk of subjective symptoms in residents suffering from SBS.
本研究旨在探讨日本新建住宅居民中化学物质与病态建筑综合征（SBS）样症状之间可能存在的关联。
我们随机抽取了 5709 套新建传统住宅。最终，425 户家庭中的 1479 位居民完成了问卷调查，并同意在其家中进行室内醛类和挥发性有机化合物（VOC）的环境监测。如果居民抱怨至少有一种与 SBS 相关的症状，则将其归类为患有 SBS。采用多变量逻辑回归分析来选择 SBS 症状的预测化学因素。
约 14%的研究对象患有 SBS。在单因素分析中，许多醛类和 VOCs 是光、鼻和咽喉症状的相关因素。在调整其他可能的危险因素后，甲醛呈剂量依赖性，是 SBS 的显著危险因素。一些化学物质有与 SBS 症状相关的趋势。
在日本新建房屋中检测到的化学物质可能会增加患有 SBS 的居民出现主观症状的风险。
