使用 Larock 环化反应简洁合成少瓣獐牙菜苦苷 F
Concise synthesis of pauciflorol F using a Larock annulation.
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
出版信息
Org Lett. 2009 Dec 3;11(23):5450-3. doi: 10.1021/ol902141z.
Abstract
A Pd-catalyzed Larock annulation provides expedient access to a subset of resveratrol-derived natural products. The reported approach resulted in the structural revision of an intermediate en route to the natural product pauciflorol F, the total synthesis of which proceeded in two steps from the requisite pentannulation product.
摘要
钯催化的 Larock 环化反应为一组特定的白藜芦醇衍生天然产物提供了简便的合成途径。所报道的方法导致了中间产物的结构修订，从而实现了天然产物 pauciflorol F 的全合成，该全合成从所需的五环化产物出发，通过两步反应进行。
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