一种通过钯催化多米诺反应合成二聚体白藜芦醇天然产物的方法。
An approach to the synthesis of dimeric resveratrol natural products via a palladium-catalyzed domino reaction.
作者信息
Jeffrey Jenna L, Sarpong Richmond
机构信息
Department of Chemistry, University of California, Berkeley, California 94720.
出版信息
Tetrahedron Lett. 2009 Apr 29;50(17):1969-1972. doi: 10.1016/j.tetlet.2009.02.067.
Abstract
A route for the rapid assembly of the carbon framework of several resveratrol natural products is presented. A palladium-catalyzed domino reaction of bromostilbene derivative 6 and tolane 7, involving two sequential Heck coupling reactions, provides access to the benzofulvene-based core of various resveratrol-derived natural products. The carbon skeleton of pallidol and its congeners is achieved by a Lewis acid-induced Nazarov-type oxidative cyclization of 9.
摘要
本文介绍了一种快速组装几种白藜芦醇天然产物碳骨架的方法。溴代芪衍生物6与苯乙炔7的钯催化多米诺反应，涉及两个连续的Heck偶联反应，可用于构建各种白藜芦醇衍生天然产物的基于苯并富烯的核心结构。通过9的路易斯酸诱导的Nazarov型氧化环化反应可得到苍白霉素及其同系物的碳骨架。
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