Department of Microbiology, University of California, Davis, CA 95616, USA.
Sci Signal. 2009 Nov 10;2(96):pe74. doi: 10.1126/scisignal.296pe74.
For decades, the fission yeast Schizosaccharomyces pombe has been used as an excellent model with which to explore how cellular growth is coordinated with the division cycle, a yet-unanswered question in biology. New studies in this organism show that TOR (target of rapamycin) kinase and stress-responsive MAPK (mitogen-activated protein kinase) form a signaling pathway that readjusts the timing of mitotic onset in response to poor nutrient conditions. Nutritional environment appears to be translated into graded activity of the protein kinases that influence the activation of Cdc2, a cyclin-dependent kinase driving cell-cycle progression.
几十年来，裂殖酵母 Schizosaccharomyces pombe 一直被用作探索细胞生长如何与分裂周期相协调的优秀模型，这是生物学中一个尚未解决的问题。该生物的新研究表明，TOR（雷帕霉素靶蛋白）激酶和应激反应性 MAPK（丝裂原活化蛋白激酶）形成了一个信号通路，根据营养条件的变化来重新调整有丝分裂起始的时间。营养环境似乎被转化为影响细胞周期进程的 cyclin-dependent kinase Cdc2 激活的蛋白激酶的分级活性。
