British Columbia Centre for Disease Control, Vancouver, BC, Canada.
Int J Cancer. 2010 Jun 15;126(12):2885-92. doi: 10.1002/ijc.25035.
We investigated whether there was an association between GBV-C viremia and the development of non-Hodgkin lymphoma (NHL) in 553 NHL cases and 438 controls from British Columbia, Canada. Cases were aged 20-79, diagnosed between March 2000 and February 2004, and resident in Greater Vancouver or Victoria. Cases and controls were tested for GBV-C RNA by RT-PCR and positive samples were genotyped. Overall, GBV-C RNA was detected in 4.5% of NHL cases vs. 1.8% of controls [adjusted odds ratio (OR) = 2.72, 95% confidence interval (CI) = 1.22-6.69]. The association between GBV-C RNA detection and NHL remained even after individuals with a history of prior transfusion, injection drug use and hepatitis C virus sero-positivity were excluded. GBV-C viremia showed the strongest association with diffuse large B cell lymphoma (adjusted OR = 5.18, 95% CI = 2.06-13.71). Genotyping was performed on 29/33 GBV-C RNA positive individuals; genotypes 2a (n = 22); 2b (n = 5) and 3 (n = 2) were identified, consistent with the distribution of genotypes found in North America. This is the largest case-control study to date associating GBV-C viremia and NHL risk. As GBV-C is known to be transmitted through blood products this may have important implications for blood safety.
我们调查了在加拿大不列颠哥伦比亚省的 553 例非霍奇金淋巴瘤 (NHL) 病例和 438 例对照中，GBV-C 病毒血症与 NHL 发展之间是否存在关联。病例年龄在 20-79 岁之间，诊断时间为 2000 年 3 月至 2004 年 2 月，居住在大温哥华或维多利亚地区。通过 RT-PCR 对病例和对照进行了 GBV-C RNA 检测，阳性样本进行了基因分型。总体而言，NHL 病例中 4.5%检测到了 GBV-C RNA，而对照组中为 1.8%（调整后的优势比[OR] = 2.72，95%置信区间[CI] = 1.22-6.69）。即使排除了有既往输血、注射吸毒和丙型肝炎病毒血清阳性史的个体，GBV-C RNA 检测与 NHL 之间的关联仍然存在。GBV-C 病毒血症与弥漫性大 B 细胞淋巴瘤的相关性最强（调整后的 OR = 5.18，95%CI = 2.06-13.71）。对 33 例 GBV-C RNA 阳性个体中的 29 例进行了基因分型；鉴定出基因型 2a（n = 22）；2b（n = 5）和 3（n = 2），与在北美发现的基因型分布一致。这是迄今为止最大的病例对照研究，将 GBV-C 病毒血症与 NHL 风险联系起来。由于已知 GBV-C 通过血液制品传播，这可能对血液安全具有重要意义。
