State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Org Lett. 2009 Dec 3;11(23):5414-7. doi: 10.1021/ol902262g.
Daphhimalenine A (1), a novel alkaloid with a rearrangement C-21 skeleton, containing a unique 1-azabicyclo[5.2.1]decane ring system, was isolated from the leaves of Daphniphyllum himalense, along with biogenetically related alkaloids daphhimalenine B (2) and daphnezomine T. Their structures were established on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by computational methods. A plausible biosynthetic pathway of 1 was also proposed.
达芙玛林碱 A（1）是一种新型生物碱，具有重排的 C-21 骨架，包含独特的 1-氮杂双环[5.2.1]癸烷环系统，从喜马拉雅达芙尼叶中分离得到，同时还分离得到了生物相关的生物碱达芙玛林碱 B（2）和达菲佐明 T。它们的结构是基于光谱数据确定的，1 的绝对构型通过计算方法确定。还提出了 1 的可能生物合成途径。
