Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Science, Beijing 100700, China.
Org Lett. 2009 Nov 19;11(22):5170-3. doi: 10.1021/ol902051v.
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
丹参酮是松香烷型二萜醌类天然产物,是中国药用植物丹参的生物活性成分。本研究基于功能基因组学对丹参酮生物合成进行了研究,首次对丹参中二萜合酶进行了功能鉴定。该研究结果表明,远端环的环己-1,4-二烯排列使生成的丹参新二烯为随后的芳构化和羟基化奠定了基础,而这正是丹参酮生物合成所需要的。