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骆驼奶对四氧嘧啶诱导糖尿病犬的降血糖作用:剂量反应试验。

Anti-diabetic effect of camel milk in alloxan-induced diabetic dogs: a dose-response experiment.

机构信息

Arid Land Institute, Livestock and Wildlife Laboratory, Medenine, Tunisia.

出版信息

J Anim Physiol Anim Nutr (Berl). 2010 Aug 1;94(4):540-6. doi: 10.1111/j.1439-0396.2009.00941.x. Epub 2009 Nov 11.

DOI:10.1111/j.1439-0396.2009.00941.x
PMID:19906135
Abstract

This study was conducted to evaluate the effect of camel milk in alloxan-induced diabetic dogs and to follow this effect at three doses of milk. Firstly, three groups of dogs were used: two groups composed each of four diabetic dogs and receiving raw camel milk (treatment 1) or cow milk (treatment 2), and four healthy dogs getting raw camel milk (treatment 3) were used as control. Each animal was treated with 500 ml of milk daily. Secondly, we compared the effects of three amounts of camel milk: 100 ml, 250 ml and 500 ml to treat the diabetic dogs. After week 3, the dogs treated with camel milk showed a statistically significant decrease in blood glucose (from 10.88 +/- 0.55 to 6.22 +/- 0.5 mmol/l) and total protein concentrations (from 78.16 +/- 2.61 g/l to 63.63 +/- 4.43 g/l). For cholesterol levels, there was a decrease from week 2 (from 6.17 +/- 0.5 mmol/l to 4.79 +/- 0.5 mmol/l). There were no significant difference in blood glucose, cholesterol or total protein concentrations in dogs drinking 250 and 500 ml of camel milk. The dogs treated with 100 ml of camel milk did not show any significant decrease in blood glucose levels, and cholesterol and total protein concentrations. The investigation was not limited to the improvement in glycemic balance, lipids and proteins control in diabetic dogs getting camel milk, but we also noted a stability of this state after the dogs stopped to drink milk. This effect depended on the quantity of camel milk used to treat diabetic dogs.

摘要

本研究旨在评估骆驼奶对四氧嘧啶诱导的糖尿病犬的影响,并观察三种剂量的骆驼奶的作用。首先,使用三组狗:两组各由四只糖尿病狗组成,分别接受生骆驼奶(治疗 1)或牛奶(治疗 2)治疗,另外四只健康狗接受生骆驼奶(治疗 3)作为对照。每只动物每天接受 500 毫升牛奶治疗。其次,我们比较了三种剂量的骆驼奶的效果:100 毫升、250 毫升和 500 毫升用于治疗糖尿病犬。第 3 周后,用骆驼奶治疗的狗血糖(从 10.88 +/- 0.55 降至 6.22 +/- 0.5 mmol/l)和总蛋白浓度(从 78.16 +/- 2.61 降至 63.63 +/- 4.43 g/l)有统计学意义的降低。胆固醇水平也从第 2 周(从 6.17 +/- 0.5 mmol/l 降至 4.79 +/- 0.5 mmol/l)下降。饮用 250 和 500 毫升骆驼奶的狗血糖、胆固醇和总蛋白浓度没有显著差异。饮用 100 毫升骆驼奶的狗血糖水平没有明显降低,胆固醇和总蛋白浓度也没有明显降低。研究不仅限于改善接受骆驼奶的糖尿病犬的血糖平衡、脂质和蛋白质控制,还注意到在狗停止饮用牛奶后这种状态的稳定性。这种效果取决于用于治疗糖尿病犬的骆驼奶的数量。

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