Hematology Laboratory, Donostia Hospital, Donostia, Spain.
Int J Lab Hematol. 2010 Jun;32(3):360-6. doi: 10.1111/j.1751-553X.2009.01194.x. Epub 2009 Nov 10.
The diagnosis of myelodysplastic syndromes (MDS) is based on morphological changes in the blood and bone marrow. The parameters NEUT-X and NEUT-Y of the Sysmex XE-2100 analyzer could help detect neutrophil dysplasia. A control group of 50 patients, along with 50 postpartum patients, 50 anemias, 50 leukopenias, 50 patients with microscopically visible hypergranulated neutrophils and 50 MDS patients were assessed. The NEUT-X and NEUT-Y values (mean +/- SD) for the control group were 1346 +/- 28.2 and 420 +/- 19.3, respectively, with the anemia and leukopenia groups giving similar values. The postpartum and hypergranulated neutrophils groups presented higher values (P < 0.05), whereas the values in the MDS group were 1286 +/- 72.8 and 385 +/- 50.9 (P < 0.05), respectively. There were no differences between the morphological MDS types. The NEUT-X and NEUT-Y values in MDS patients with optical hypogranulation were significantly lower than for MDS patients without optical hypogranulation. NEUT-X and NEUT-Y values lower than 1298 and 398, respectively, would have a specificity for detecting MDS of 94% and 91% and would detect 60% and 56% of cases, respectively, whereas they would detect 75% and 74%, respectively, of MDS cases with optical hypogranulation. NEUT-X and NEUT-Y parameters can be used to detect neutrophil dysplasia arising from MDS and chronic myelomonocytic leukemia.
骨髓增生异常综合征（MDS）的诊断基于血液和骨髓的形态学变化。Sysmex XE-2100 分析仪的 NEUT-X 和 NEUT-Y 参数可帮助检测中性粒细胞发育不良。评估了 50 名患者（对照组），以及 50 名产后患者、50 名贫血患者、50 名白细胞减少症患者、50 名显微镜下可见颗粒增多的中性粒细胞患者和 50 名 MDS 患者。对照组的 NEUT-X 和 NEUT-Y 值（平均值±SD）分别为 1346±28.2 和 420±19.3，贫血和白细胞减少症组的数值相似。产后和颗粒增多的中性粒细胞组的数值较高（P<0.05），而 MDS 组的数值分别为 1286±72.8 和 385±50.9（P<0.05）。形态学 MDS 类型之间没有差异。光学颗粒减少的 MDS 患者的 NEUT-X 和 NEUT-Y 值明显低于无光学颗粒减少的 MDS 患者。低于 1298 和 398 的 NEUT-X 和 NEUT-Y 值的特异性分别为 94%和 91%，可分别检测到 60%和 56%的 MDS 病例，而光学颗粒减少的 MDS 病例的特异性分别为 75%和 74%。NEUT-X 和 NEUT-Y 参数可用于检测 MDS 和慢性髓单核细胞白血病引起的中性粒细胞发育不良。
