Aguadero Vicente, López María, Ruíz Míriam, Regidor Diana, Celma Gemma
Laboratory of Sant Joan Despí Moisès Broggi Hospital, Consorci del Laboratori Intercomarcal de l'Alt Penedès, l'Anoia i el Garraf (CLILAB Diagnòstics), Vilafranca del Penedès, Barcelona, Spain.
Laboratoy of Vilafranca Del Penedès, Consorci del Laboratori Intercomarcal de l'Alt Penedès, l'Anoia i el Garraf (CLILAB Diagnòstics), Vilafranca del Penedès, Barcelona, Spain.
Adv Lab Med. 2025 Feb 4;6(1):98-102. doi: 10.1515/almed-2025-0003. eCollection 2025 Mar.
Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by peripheral blood cytopenias, cellular dysplasia and risk for progression into acute leukemia. Recent studies reveal that some research parameters available on Sysmex XN-1000 hematology analyzers, including immature platelet fraction (IPF), Neutrophil Granularity Index (Neu-GI), or platelet distribution width (PDW), show a relationship with dysplasia in peripheral blood. The objective of this study was to examine the association between classic and research blood count parameters and the presence of dysplasia. The secondary objective was to develop a multivariate model that allows the prediction of dysplasia with high probability.
Seventy-five patients older than 60 years with anemia, leukopenia or thrombocytopenia, without vitamin B12 and folate deficiency or hematological diseases underwent testing with the Sysmex XN-1000 analyzer.
Dysplasia was confirmed in 32 % of patients, with significant differences in Neu-GI, PDW and IPF count between the groups of patients with and without dysplasia. Neu-GI was the parameter with the highest predictive value (AUC=0.98), with such value not increasing significantly after the addition of PDW or PIF. A Neu-GI value≤146ch predicts dysplasia with a positive predictive value=90 %.
Neu-GI is the parameter most strongly associated with dysplasia. A Neu-GI value≤146ch indicates a high probability of dysplasia and supports indication for a blood smear review. Additionally, values>152ch indicate a low probability of dysplasia.
骨髓增生异常综合征（MDS）是一种克隆性造血疾病，其特征为外周血细胞减少、细胞发育异常以及进展为急性白血病的风险。近期研究表明，Sysmex XN - 1000血液分析仪提供的一些研究参数，包括未成熟血小板分数（IPF）、中性粒细胞颗粒指数（Neu - GI）或血小板分布宽度（PDW），与外周血发育异常存在关联。本研究的目的是检验经典和研究性血细胞计数参数与发育异常存在之间的关联。次要目的是建立一个能够高概率预测发育异常的多变量模型。
75名年龄大于60岁、患有贫血、白细胞减少或血小板减少症、无维生素B12和叶酸缺乏或血液系统疾病的患者接受了Sysmex XN - 1000分析仪检测。
32%的患者确诊存在发育异常，有发育异常和无发育异常的患者组之间在Neu - GI、PDW和IPF计数上存在显著差异。Neu - GI是预测价值最高的参数（曲线下面积[AUC]=0.98），添加PDW或PIF后该值未显著增加。Neu - GI值≤146ch预测发育异常的阳性预测值为90%。
Neu - GI是与发育异常关联最密切的参数。Neu - GI值≤146ch表明发育异常的可能性很高，并支持进行血涂片复查。此外，值>152ch表明发育异常的可能性较低。
