牛至和蔓越莓提取物的延寿作用依赖于饮食，这在墨西哥果蝇（Anastrepha ludens）中得到了证实。
Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens).
机构信息
Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2010 Jan;65(1):41-50. doi: 10.1093/gerona/glp176. Epub 2009 Nov 11.
Abstract
Botanicals have numerous health benefits. Here, we used the Mexican fruit fly to screen 14 compounds and botanicals for their prolongevity effects and found an oregano and cranberry mixture (OC) improved survival. We then evaluated prolongevity effects of OC within the context of diet composition. Individual flies were fed 0%, 1%, or 2% OC in one of the three diets containing sugar and yeast extract (SY) at a ratio of 3:1, 9:1, or 24:1. We found that prolongevity effects of OC depended upon dose, gender, and diet composition. The greatest increase in longevity was observed in females fed the SY24:1 diet with 2% OC compared to the non-supplemented diet. OC did not reduce egg laying and, hence, did not compromise fecundity under any dietary condition tested here. This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender.
摘要
植物药有许多健康益处。在这里，我们使用墨西哥果蝇来筛选 14 种化合物和植物药，以观察它们的延寿效果，发现一种牛至和蔓越莓混合物（OC）能提高存活率。然后，我们在饮食组成的背景下评估 OC 的延寿效果。将 OC 以 0%、1%或 2%的剂量添加到三种饮食中的一种中，三种饮食中糖和酵母提取物（SY）的比例分别为 3:1、9:1或 24:1，单独的果蝇食用这些饮食。我们发现 OC 的延寿效果取决于剂量、性别和饮食组成。在喂食 SY24:1 饮食的雌性果蝇中，OC 的添加量为 2%，与未补充 OC 的饮食相比，其寿命延长的幅度最大。OC 并没有减少产卵，因此在任何测试的饮食条件下都没有损害生育能力。本研究揭示了 OC 的延寿效果，并支持了这样一种观点，即植物药对衰老的益处取决于饮食组成和性别。
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