Department of Neurology, Kuopio University Hospital, FI-70211 Kuopio, Finland.
Dement Geriatr Cogn Disord. 2009;28(5):404-12. doi: 10.1159/000256274. Epub 2009 Nov 10.
BACKGROUND/AIMS: Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment.
We assessed the baseline MRI and maximum of 7 years clinical follow-up data of 60 MCI subjects in order to examine differences in cortical thickness (CTH) between the progressive MCI (P-MCI) and stable MCI (S-MCI) subjects. CTH was measured using an automatic computational surface-based method. During the follow-up, 15 MCI subjects converted to AD on average 1.9 +/- 1.3 years after the baseline examination, while 45 MCI subjects remained stable.
The P-MCI group displayed significantly reduced CTH bilaterally in the superior and middle frontal, superior, middle and inferior temporal, fusiform and parahippocampal regions as well as the cingulate and retrosplenial cortices and also in the right precuneal and paracentral regions compared to S-MCI subjects.
Analysis of CTH could be used in conjunction with neuropsychological testing to identify those subjects with imminent conversion from MCI to AD several years before dementia diagnosis.
背景/目的：轻度认知障碍（MCI）与阿尔茨海默病（AD）的风险增加有关。如果希望监测疾病的发展和治疗，那么能够区分那些有较高进展为 AD 风险的 MCI 患者的特征将是有利的。
我们评估了 60 名 MCI 受试者的基线 MRI 和最多 7 年的临床随访数据，以检查进展性 MCI（P-MCI）和稳定 MCI（S-MCI）受试者之间皮质厚度（CTH）的差异。使用自动计算的基于表面的方法测量 CTH。在随访期间，平均有 15 名 MCI 受试者在基线检查后 1.9 +/- 1.3 年转化为 AD，而 45 名 MCI 受试者保持稳定。
与 S-MCI 受试者相比，P-MCI 组双侧额上、中回，额上、中、下回，梭状回和海马旁回，扣带回和后扣带回皮质以及右侧楔前叶和旁中央叶的 CTH 明显减少。
分析 CTH 可以与神经心理学测试结合使用，以在痴呆诊断前几年识别出那些即将从 MCI 转化为 AD 的受试者。
