Pierce Arand, Miller Geoffrey, Arden Rosalind, Gottfredson Linda S
Department of Pathology; School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Commun Integr Biol. 2009 Sep;2(5):385-7. doi: 10.4161/cib.2.5.8716.
We recently found positive correlations between human general intelligence and three key indices of semen quality, and hypothesized that these correlations arise through a phenotype-wide 'general fitness factor' reflecting overall mutation load. In this addendum we consider some of the biochemical pathways that may act as targets for pleiotropic mutations that disrupt both neuron function and sperm function in parallel. We focus especially on the inter-related roles of polyunsaturated fatty acids, exocytosis and receptor signaling.
我们最近发现人类一般智力与精液质量的三个关键指标之间存在正相关，并推测这些相关性是通过反映整体突变负荷的全表型“一般健康因素”产生的。在本附录中，我们考虑了一些可能作为多效性突变靶点的生化途径，这些突变会同时破坏神经元功能和精子功能。我们特别关注多不饱和脂肪酸、胞吐作用和受体信号传导之间的相互关系。
