Animal Management, Bayer Schering Pharma AG, Wuppertal, Germany.
ALTEX. 2009;26(3):177-85. doi: 10.14573/altex.2009.3.177.
In vivo luminescent imaging technology was introduced in experimental life science research several years ago and has rapidly gained wide acceptance. By making use of this technology substantially more information can be gained from animal experiments than was previously possible. The concept of the 3Rs describes the aim to Refine, Reduce and Replace animal models in research. The goal of the present paper is to systematically investigate the impact of luminescent imaging on the 3Rs. In particular, three examples of applications are explained in detail so as to be accessible to the reader unfamiliar with the procedure. The examples are subsequently analysed for and categorised according to their concrete effect on animal welfare as defined by the 3Rs.
体内发光成像技术在几年前被引入实验生命科学研究领域，迅速获得了广泛的认可。通过利用这项技术，可以从动物实验中获得比以前更多的信息。3R 概念描述了在研究中改进、减少和替代动物模型的目标。本文的目的是系统地研究发光成像对 3R 的影响。特别是，详细解释了三个应用示例，以便让不熟悉该程序的读者能够理解。随后，根据 3R 定义的动物福利的具体影响对这些示例进行了分析和分类。
