Department of Psychology, University of Birmingham, Birmingham, UK.
J Psychosom Res. 2009 Dec;67(6):503-13. doi: 10.1016/j.jpsychores.2009.08.001.
Tourette syndrome (TS) is assumed to result from frontostriatal dysfunction, which would be expected to result in impairments in neuropsychological functions. This possibility has been explored in a number of studies that have assessed the performance of patients with TS within major cognitive domains and on tests involving executive functioning. We aim to summarize the main findings of these studies while evaluating the influence of task limitations and potentially critical confounding factors such as the presence of comorbidity. Although there is clearly a need for improved study design, we tentatively suggest that there is considerable evidence for cognitive impairment in a subgroup of patients, and that some difficulties seem to be intrinsic to TS. These impairments may reflect dysfunction of the anterior cingulate network within the frontostriatal pathway.
妥瑞氏症（TS）被认为是由于额纹状体功能障碍引起的，这可能导致神经心理功能受损。已经有许多研究探索了这种可能性，这些研究评估了 TS 患者在主要认知领域的表现，以及在涉及执行功能的测试中的表现。我们旨在总结这些研究的主要发现，同时评估任务限制和潜在关键混杂因素（如合并症的存在）的影响。尽管显然需要改进研究设计，但我们暂提议，在一个亚组患者中存在相当多的认知障碍证据，并且一些困难似乎是 TS 所固有的。这些损伤可能反映了额纹状体通路中前扣带网络的功能障碍。
