Department of Radiology, Hokkaido University Hospital, N15 W7, kita-ku, Sapporo City, 0608638, Japan.
Eur J Radiol. 2011 Apr;78(1):151-6. doi: 10.1016/j.ejrad.2009.10.005. Epub 2009 Nov 14.
To evaluate the relationship between renal cortical volume, measured by an automatic contouring software, with body mass index (BMI), age and renal function.
The study was performed in accordance to the institutional guidelines at our hospital. Sixty-four patients (34 men, 30 women), aged 19 to 79 years had their CT scans for diagnosis or follow-up of hepatocellular carcinoma retrospectively examined by a computer workstation using a software that automatically contours the renal cortex and the renal parenchyma. Body mass index and estimated glomerular filtration rate (eGFR) were calculated based on data collected. Statistical analysis was done using the Student t-test, multiple regression analysis, and intraclass correlation coefficient (ICC).
The ICC for total renal and renal cortical volumes were 0.98 and 0.99, respectively. Renal volume measurements yielded a mean cortical volume of 105.8cm(3)±28.4SD, mean total volume of 153cm(3)±39SD and mean medullary volume of 47.8cm(3)±19.5SD. The correlation between body weight/height/BMI and both total renal and cortical volumes presented r=0.6, 0.6 and 0.4, respectively, p<0.05, while the correlation between renal cortex and age was r=-0.3, p<0.05. eGFR showed correlation with renal cortical volume r=0.6, p<0.05.
This study demonstrated that renal cortical volume had a moderate positive relationship with BMI, moderate negative relationship with age, and a strong positive relationship with the renal function, and provided a new method to routinely produce volumetric assessment of the kidney.
评估通过自动轮廓软件测量的肾皮质体积与体重指数（BMI）、年龄和肾功能之间的关系。
该研究是在我们医院的机构指南的指导下进行的。回顾性地对 64 名年龄在 19 至 79 岁的男性 34 名和女性 30 名患者进行 CT 扫描，用于诊断或随访肝细胞癌，由计算机工作站使用自动轮廓软件对肾皮质和肾实质进行检查。根据收集的数据计算 BMI 和估算肾小球滤过率（eGFR）。使用学生 t 检验、多元回归分析和组内相关系数（ICC）进行统计分析。
总肾和肾皮质体积的 ICC 分别为 0.98 和 0.99。肾体积测量得出平均皮质体积为 105.8cm³±28.4SD，平均总体积为 153cm³±39SD，平均髓质体积为 47.8cm³±19.5SD。体重/身高/BMI 与总肾和皮质体积均呈中度正相关，分别为 r=0.6、0.6 和 0.4，p<0.05，而肾皮质与年龄呈中度负相关，r=-0.3，p<0.05。eGFR 与肾皮质体积呈中度正相关，r=0.6，p<0.05。
本研究表明，肾皮质体积与 BMI 呈中度正相关，与年龄呈中度负相关，与肾功能呈强烈正相关，为常规进行肾脏体积评估提供了一种新方法。
