Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
Wien Klin Wochenschr. 2009 Oct;121 Suppl 3:23-6. doi: 10.1007/s00508-009-1230-7.
The habitats of Eurycoma longifolia Jack, a slender tree, are jungles in Malaysia and Indonesia. It belongs to the family Simaroubaceae and is a source of quassinoids with anabolic, antimalarial and cytostatic activity. In this study, conducted during 2008 in Mae Sot, Thailand, a standardized extract of E. longifolia containing three major quassinoids, eurycomanone (1), 13,21-dihydroeurycomanone (2) and 13alpha(21)-epoxyeurycomanone (3) was evaluated for antiplasmodial activity against Plasmodium falciparum and its activity has been compared with that of artemisinin, using 38 fresh parasite isolates and assessment of inhibition of schizont maturation. The IC(50), IC(90) and IC(99) values for artemisinin were 4.30, 45.48 and 310.97 microg/l, and those for the root extract from E. longifolia 14.72, 139.65 and 874.15 microg/l respectively. The GMCOC for artemisinin was 337.81 mug/l, and for the plant extract it was 807.41 microg/l. The log-concentration probit regressions were parallel. The inhibitory activity of the E. longifolia extract was higher than that expected from the three quassinoids isolated from the plant, suggesting synergism between the quassinoids or the presence of other unidentified compounds.
长叶勾儿茶（Eurycoma longifolia Jack）是一种细长的树木，其栖息地是马来西亚和印度尼西亚的丛林。它属于苦木科，是具有同化作用、抗疟疾和细胞抑制活性的奎宁类化合物的来源。在这项于 2008 年在泰国湄索进行的研究中，对含有三种主要奎宁类化合物（eurycomanone（1）、13,21-二氢 eurycomanone（2）和 13alpha（21）-环氧 eurycomanone（3）的标准化长叶勾儿茶提取物进行了抗疟原虫活性评估，与青蒿素进行了比较，使用 38 个新鲜寄生虫分离株，并评估了裂殖体成熟的抑制作用。青蒿素的 IC50、IC90 和 IC99 值分别为 4.30、45.48 和 310.97μg/l，长叶勾儿茶根提取物的 IC50、IC90 和 IC99 值分别为 14.72、139.65 和 874.15μg/l。青蒿素的 GMCOC 为 337.81μg/l，植物提取物的 GMCOC 为 807.41μg/l。对数浓度概率回归是平行的。长叶勾儿茶提取物的抑制活性高于从植物中分离出的三种奎宁类化合物的预期值，这表明奎宁类化合物之间存在协同作用或存在其他未鉴定的化合物。
