Ang H H, Chan K L, Mak J W
Planta Med. 1995 Apr;61(2):177-8. doi: 10.1055/s-2006-958042.
Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.
对从长叶刺蕊草根部提取的三种苦木素类化合物进行了抗疟活性评估，受试对象为从感染耐氯喹疟疾患者中分离出的9株恶性疟原虫。结果表明，刺蕊草醇、刺蕊草醇2 - O - β - D - 吡喃葡萄糖苷和13β,18 - 二氢刺蕊草醇具有抗疟活性，其半数抑制浓度（IC50）值分别为1.231 - 4.899微摩尔/升、0.389 - 3.498微摩尔/升和0.504 - 2.343微摩尔/升，而氯喹的IC50值为0.323 - 0.774微摩尔/升。
