Mohd Ridzuan M A R, Sow A, Noor Rain A, Mohd Ilham A, Zakiah I
Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia.
Trop Biomed. 2007 Jun;24(1):111-8.
Eurycoma longifolia, locally known as 'Tongkat Ali' is a popular local medicinal plant that possess a lot of medicinal properties as claimed traditionally, especially in the treatment of malaria. The claims have been proven scientifically on isolated compounds from the plant. The present study is to investigate the anti malaria properties of Eurycoma longifolia standardized extract (root) (TA164) alone and in combination with artemisinin in vivo. Combination treatment of the standardized extract (TA164) with artemisinin suppressed P. yoelii infection in the experimental mice. The 4 day suppressive test showed that TA164 suppressed the parasitemia of P. yoelii-infected mice as dose dependent manner (10, 30 and 60 mg/kg BW) by oral and subcutaneous treatment. By oral administration, combination of TA164 at 10, 30 and 60 mg/kg BW each with artemisinin respectively showed a significant increase in the parasitemia suppression to 63, 67 and 80 percent as compared to artemisinin single treatment (31%). Using subcutaneous administration, at 10 mg/kg BW of TA164 in combination with 1.7 mg/kg BW of artemisinin gave a suppression of 80% of infection. This study showed that combination treatment of TA164 with artemisinin gives a promising potential anti malaria candidate using both oral and subcutaneous route, the later being the most potent.
长叶刺蒺藜草，当地称为“东革阿里”，是一种广受欢迎的当地药用植物，传统上声称具有许多药用特性，尤其是在治疗疟疾方面。从该植物中分离出的化合物已在科学上证实了这些说法。本研究旨在调查长叶刺蒺藜草标准化提取物（根）（TA164）单独以及与青蒿素联合使用时在体内的抗疟特性。标准化提取物（TA164）与青蒿素联合治疗可抑制实验小鼠中的约氏疟原虫感染。为期4天的抑制试验表明，TA164通过口服和皮下给药以剂量依赖方式（10、30和60毫克/千克体重）抑制约氏疟原虫感染小鼠的寄生虫血症。通过口服给药，TA164分别以10、30和60毫克/千克体重与青蒿素联合使用时，与青蒿素单一治疗（31%）相比，寄生虫血症抑制率显著提高至63%、67%和80%。使用皮下给药，10毫克/千克体重的TA164与1.7毫克/千克体重的青蒿素联合使用可抑制80%的感染。本研究表明，TA164与青蒿素联合治疗通过口服和皮下途径均显示出有前景的潜在抗疟候选药物，皮下途径最为有效。
