Laboratory of Medical Investigation, Urology Department–LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil.
In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):131-9. doi: 10.1007/s11626-009-9252-z.
Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and established in the seventies or eighties. Thus, neoplasia development in these cells likely occurred in environment conditions vastly different than today. In the present study, we report the establishment and characterization of three Brazilian bladder cancer cell lines (BexBra1, BexBra2, and BexBra4). These cell lines may be helpful for dissecting the genetic and epigenetic aspects that trigger the progression of BC. Moreover, the development of a Brazilian representative of the disease will allow us to investigate the potential inter-racial differences of malignancy-associated phenotypes in bladder cancer.
膀胱癌（BC）是美国第四大常见癌症。在巴西，BC 占人群中现有癌总数的 3%，是泌尿系统肿瘤中发病率第二高的肿瘤。目前可用的大多数膀胱癌细胞系均源自白种人，并且是在 70 年代或 80 年代建立的。因此，这些细胞中的肿瘤发生很可能发生在与今天大不相同的环境条件下。在本研究中，我们报告了三种巴西膀胱癌细胞系（BexBra1、BexBra2 和 BexBra4）的建立和特征。这些细胞系可能有助于剖析引发 BC 进展的遗传和表观遗传方面。此外，开发出具有代表性的巴西疾病模型将使我们能够研究膀胱癌中与恶性表型相关的潜在种族间差异。
