Meining Alexander
Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstr. 22, 81675 Munich, Germany.
Gastrointest Endosc Clin N Am. 2009 Oct;19(4):629-35. doi: 10.1016/j.giec.2009.07.005.
The preoperative diagnosis of biliary neoplasms is associated with a low sensitivity. To overcome this limitation, probe-based confocal laser endomicroscopy was further developed to enable in vivo microscopic imaging, with confocal miniprobes further miniaturized to such an extent to enable their use even via the instrumentation channel of cholangioscopes. The current data available suggest that this new technology represents a promising approach for further differentiation of strictures and stenosis in the biliary, and perhaps also pancreatic system. Nevertheless, those results are based on a limited number of patients; further studies involving more patients examined at various centers are necessary and already under way to prove the true clinical importance of this new imaging modality.
胆管肿瘤的术前诊断敏感性较低。为克服这一局限性，基于探头的共聚焦激光内镜技术得到进一步发展，以实现体内显微成像，共聚焦微型探头进一步小型化，甚至可通过胆管镜的器械通道使用。现有数据表明，这项新技术是进一步鉴别胆管及可能的胰腺系统狭窄和缩窄的一种有前景的方法。然而，这些结果基于有限数量的患者；有必要且正在进行更多涉及不同中心更多患者的进一步研究，以证明这种新成像方式的真正临床重要性。
