EA 4090 Substances Licheniques et Photoprotection, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France.
J Nat Prod. 2009 Dec;72(12):2177-80. doi: 10.1021/np9003728.
A new diphenyl ether (1), along with 12 known compounds, was isolated from the lichen Diploicia canescens. The structure of compound 1 was elucidated by spectroscopic data analysis, and the biosynthetic origin of this product is discussed. Secalonic acids B (7), D (8), and F (9) were isolated for the first time from D. canescens. The cytotoxic activities of 1-3, 6-8, and 10 against the B16 murine melanoma and HaCaT human keratinocyte cell lines were evaluated.
从地茶 Diploicia canescens 中分离得到一种新的二苯醚（1）和 12 种已知化合物。通过光谱数据分析阐明了化合物 1 的结构，并讨论了该产物的生物合成来源。首次从 D. canescens 中分离得到 secalonic 酸 B（7）、D（8）和 F（9）。评估了 1-3、6-8 和 10 对 B16 小鼠黑色素瘤和 HaCaT 人角质形成细胞系的细胞毒性活性。
