海洋来源 的二苯醚类化合物
Diphenyl Ethers from a Marine-Derived .
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Mar Drugs. 2018 Nov 16;16(11):451. doi: 10.3390/md16110451.
Six new diphenyl ethers (⁻) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds and are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds ⁻ was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds , , , and ⁻ were found to exhibit selective cytotoxicity against different cancer cell lines.
从海洋来源的 中通过 LC-UV-MS 指导的乙酸乙酯提取物中分离出六种新的二苯醚（⁻）和十一种已知类似物。通过高分辨质谱、NMR 以及化学衍生化等方法明确了它们的结构。化合物 和 是罕见的含 d-核糖的二苯醚糖苷。通过 LC-MS 方法确定了化合物 ⁻ 中糖部分的绝对构型。所有化合物均针对包括 4T1、U937、PC3、HL-60、HT-29、A549、NCI-H460 和 K562 在内的八种癌细胞系进行了细胞毒性评估，发现化合物 、 、 、 和 ⁻ 对不同的癌细胞系具有选择性细胞毒性。
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