Department of Polymer Science and Engineering, Inha University, Incheon 402-751, Korea.
J Am Chem Soc. 2009 Nov 25;131(46):16614-5. doi: 10.1021/ja9061085.
The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.
被环糊精覆盖的多孔硅纳米颗粒（Si-MPs）表现出了酶响应的特性。Si-MPs 表面的环糊精“守门员”可以被α-淀粉酶水解，从而将客体分子从多孔储库中释放出来。环糊精“守门员”的侧链部分的酯键也可以被脂肪酶切断，从而将通道中的客体分子释放出来。我们的方法将为控制释放系统提供一种独特的方法。
