Zeller Rolf, López-Ríos Javier, Zuniga Aimée
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland.
Nat Rev Genet. 2009 Dec;10(12):845-58. doi: 10.1038/nrg2681.
The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud signalling system that involves many of the pathways that are known to regulate morphogenesis. These findings contrast with the prevailing view that the main limb bud axes develop largely independently of one another. In this Review, we discuss models of limb development and attempt to integrate the current knowledge of the signalling interactions that govern limb skeletal development into a systems model. The resulting integrative model provides insights into how the specification and proliferative expansion of the anteroposterior and proximodistal limb bud axes are coordinately controlled in time and space.
肢体芽对理解脊椎动物器官发生具有典范性价值。最近对小鼠的基因分析揭示，存在一个很大程度上自我调节的肢体芽信号系统，该系统涉及许多已知调节形态发生的信号通路。这些发现与普遍观点形成对比，即主要的肢体芽轴在很大程度上彼此独立发育。在本综述中，我们讨论肢体发育模型，并试图将目前关于控制肢体骨骼发育的信号相互作用的知识整合到一个系统模型中。由此产生的整合模型为前后轴和近远轴肢体芽的特化和增殖扩展如何在时间和空间上得到协调控制提供了见解。
