Division of Infectious Diseases, Department of Social and Environmental Medicine, Institute of Scientific Research, Oita University, Yufu 879-5593, Oita, Japan.
Arch Virol. 2010;155(1):71-5. doi: 10.1007/s00705-009-0552-0. Epub 2009 Nov 17.
Rotavirus diarrhea is an important cause of child mortality in developing countries, but studies on this diarrhea are scarce in Sri Lanka. A prospective study conducted in Sri Lanka on rotavirus infection among children in a hospital setting (n = 611) versus children residing in tsunami camps (n = 52) showed that prevalence of rotavirus infection was comparable, 21.9 and 20%, respectively. The hospital and camps were located in different districts. Analysis of the genotypes of 122 rotaviruses from the hospital and 12 from the camps indicated that G9P[8] was associated with 35 and 33%; G12P[8/nt] with 14.7 and 33%; G3P[8/4/nt] with 17 and 8% and G1P[8/4] with 6.5 and 16.7%. Rotaviruses with G2P[8/4/6] and G4P[8/4] were hospital-associated only, and some rotaviruses (9 and 8% from the hospital and the camps, respectively) were G- and P-nontypable. We conclude from the present study that multiple emerging genotypes were prevalent in Sri Lanka, and children in camps were at risk of developing diarrhea due to rotaviruses.
轮状病毒腹泻是发展中国家儿童死亡的重要原因，但斯里兰卡关于这种腹泻的研究很少。一项在斯里兰卡医院环境中（n = 611）和海啸难民营中（n = 52）儿童中进行的前瞻性研究表明，轮状病毒感染的患病率相似，分别为 21.9%和 20%。医院和营地位于不同的地区。对来自医院的 122 株轮状病毒和来自营地的 12 株轮状病毒的基因型进行分析表明，G9P[8]与 35%和 33%相关；G12P[8/8]与 14.7%和 33%相关；G3P[8/4/nt]与 17%和 8%相关，G1P[8/4]与 6.5%和 16.7%相关。具有 G2P[8/4/6]和 G4P[8/4]的轮状病毒仅与医院相关，一些轮状病毒（分别来自医院和营地的 9%和 8%）为 G 和 P 非定型。本研究得出的结论是，多种新兴基因型在斯里兰卡流行，营地中的儿童有患轮状病毒腹泻的风险。
Zotero 插件